Spermidine 3HCL 15ml Solution (90mg)

What is Spermidine?

Spermidine is a naturally occuring polyamine compound that is found in ribosomes and living tissues. It has various metabolic functions within organisms and was originally isolated from semen. Spermidine helps regulate biological processes like calcium and sodium ion homeostasis, cell growth and proliferation, and cell death. It also plays a role in DNA and RNA regulation and stability. Additionally, spermidine acts as an antioxidant and anti-inflammatory agent. Spermidine is synthesized from the amino acid ornithine and is a precursor for other polyamines like spermine. 

Spermidine and Longevity

Spermidine has been the subject of numerous studies due to its potential role in promoting longevity. The compound is found in foods like aged cheese and whole grains and has been linked to lifespan extension in various organisms, including yeast, flies, worms, and mammals.

A 2023 study found that nutritional supplementation with spermidine could reduce age-related pathology and increase lifespan in several organisms, including humans. This research suggested that spermidine might play a role in cell homeostasis, with increased levels of polyamine synthesizing enzymes associated with cell proliferation [R].

Another study from the same year found that a long-term, high polyamine diet, which increases spermine (a polyamine closely related to spermidine), could suppress aberrant gene methylation and inflammation that progress with age. These conditions are strongly associated with the development of several age-related diseases and senescence [R].

In 2020, research showed that spermidine could promote autophagy in cardiac muscle, a vital process for the recycling of dysfunctional and potentially harmful cellular components. This process could prevent interruptions in the homeostatic environment and prevent disease, making spermidine a promising candidate for further research into treatments for age-related cardiac decline [R].

Finally, a 2024 review highlighted the potential of plant-derived compounds, including spermidine, as pro-longevity agents [R].

Spermidine and Autophagy

Spermidine has been studied for its potential to induce autophagy, a cellular process that recycles and removes unnecessary or dysfunctional components. This process is important for maintaining cellular health and function, and its enhancement has been linked to a broad range of health benefits.

In a 2023 study, researchers found that exogenous spermidine could induce autophagy and reduce oxidative stress in the ovaries and granulosa cells of Sichuan white geese. This study showed that spermidine could increase the levels of autophagy-associated proteins, thereby reducing the accumulation of reactive oxygen species and the rate of apoptosis [R].

Another study from 2023 found that a supplement combining spermidine and eugenol, a compound found in clove oil, could stimulate autophagy in human intestinal cells. The supplement was found to reduce inflammation and increase autophagy, suggesting potential benefits for intestinal health [R].

In 2022, a study linked many of the cellular effects of spermidine to autophagy. The researchers suggested that enhancing autophagy could be a strategy for protecting against age-related diseases [R].

A 2019 study found that spermidine could protect against liver injury caused by ischemia-reperfusion, a condition that occurs when blood supply returns to tissue after a period of ischemia or lack of oxygen. The researchers found that spermidine regulated autophagy through the AMPK-mTOR-ULK1 signaling pathway, suggesting potential benefits for liver health [R].

In 2020, a study highlighted spermidine’s role in promoting autophagy in cardiac muscle, which could help prevent cardiac dysfunction. The researchers suggested that spermidine could be a promising candidate for further research into treatments for age-related cardiac decline [R].