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L-Glutathione (500mg)


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Sterile Vial (10 mL)

Reference Standard 99%+


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L-Glutathione Supplement Overview

L-Glutathione, also known as GSH, is a tripeptide composed of the amino acids glycine, cysteine, and glutamic acid.  It is synthesized by the liver and plays a role in multiple bodily functions such as tissue regeneration, chemical and protein production, and immune system support. Glutathione acts as a powerful antioxidant, shielding cells from harm caused by free radicals and reactive oxygen species. It is present in various organisms, including plants, animals, fungi, bacteria, and archaea.

Glutathione is a Powerful Antioxidant

Glutathione (GSH) is a powerful antioxidant that is found in every cell of the body. It helps stave off the impact of oxidative stress, which may, in turn, reduce the risk of developing diseases such as diabetes, cancer, and rheumatoid arthritis. It can act directly as an antioxidant to protect cells against free radicals and pro-oxidants. GSH is involved in multiple cellular processes including protein folding, safeguarding protein thiols from oxidation and crosslinking, breaking down proteins with disulfide bonds, regulating cell cycle and proliferation, metabolizing ascorbate, inducing apoptosis, and promoting ferroptosis.

GSH is known to minimize the lipid peroxidation of cellular membranes and other such targets that occur with oxidative stress. Maintaining an optimal balance of GSH is necessary for effectively preventing peroxidation of the lipid membranes.

Glutathione and the Immune System

Glutathione plays a crucial role in supporting the immune system. It regulates the balance between innate immunity or leukocyte infiltration at the site of infection to kill bacteria and inflammation. The lymphoid cells function optimally when the level of glutathione is delicately balanced. Even slight alterations in the intracellular glutathione level can significantly impact the functions of lymphocytes.

Glutathione is essential for the growth of T cells. T cells lacking glutathione are unable to increase in size, greatly affecting their performance by restricting their ability to expand in both cell size and numbers. Glutathione regulates the levels of free radicals in T cells, safeguarding against DNA damage and cell death. This is crucial because T cells require increased energy and metabolic activity during proliferation, leading to the production of free radicals.

Glutathione and Detoxification

Glutathione is involved in various detoxification processes, including the excretion of harmful substances from cells and the transformation of fat-soluble toxins into water-soluble toxins for elimination from the body. Glutathione attaches to harmful substances and toxins, identifying them as dangerous and aiding in their removal from the body. This is important for eliminating external chemicals and substances, like drugs and environmental pollutants.

Glutathione helps convert toxins into mercapturic acid, which can then be eliminated from the body through urine. This process is important for transforming the previously harmful substances into a state that can be further metabolized or expelled.

Glutathione and Skin Health

Glutathione has been the subject of research in relation to its effects on skin health, particularly in skin lightening and anti-aging. Some studies have shown that supplementation of reduced form of glutathione (GSH) has a skin-lightening efficacy in humans. A systematic review also provided comprehensive evidence that oral glutathione tends to brighten skin tone, but statistical significance was observed in 500 mg doses.


What is L-Glutathione?

L-Glutathione, or GSH, is a natural antioxidant produced in the body through enzymatic reactions using the amino acids cysteine, L-glutamic acid, and glycine. It can be found in plants, animals, fungi, bacteria, and archaea, and has the ability to protect vital cellular components from damage caused by reactive oxygen species, free radicals, peroxides, lipid peroxides, and heavy metals.

What are the Researched Benefits of L-Glutathione?

Glutathione is a potent antioxidant that has been researched for numerous potential benefits. Here are some of the main advantages of glutathione:

  • Antioxidant properties: Glutathione helps counteract free radicals and safeguards the body against their harmful effects. Free radicals can contribute to aging and various diseases, but antioxidants like glutathione help minimize their impact.
  • Reduced oxidative stress: Glutathione helps combat oxidative stress, which may lower the risk of multiple diseases, including diabetes, cancer, and rheumatoid arthritis.
  • Enhanced immune function: Glutathione is important for proper immune system function. It supports the production of white blood cells and aids in fighting off infections and diseases.
  • Improved detoxification: Glutathione plays a vital role in eliminating toxins, drugs, and pollutants from the body. It assists the liver and gallbladder in processing fats and removing mercury from the brain.
  • Protection against chronic conditions: Low levels of glutathione have been linked to a higher risk of cancer, type 2 diabetes, hepatitis, and Parkinson’s disease. Increasing glutathione levels may help reduce the risk of these and other chronic conditions.
  • Better skin health: Glutathione may improve certain skin conditions, such as psoriasis, by reducing inflammation and protecting against the harmful effects of oxidative stress.
  • Support for respiratory health: Glutathione has been associated with improved lung health in preterm infants and may aid in increasing mobility in peripheral artery disease.
  • Potential anti-aging effects: Some believe that glutathione possesses anti-aging properties, although more research is needed to fully understand its role in the aging process.

To naturally increase glutathione levels, consider reducing toxin exposure, consuming nutritious foods, and consider supplements that support glutathione production, such as L-glutathione, curcumin, selenium, vitamin C and vitamin E.

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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