Research
Ibutamoren (MK677) Fact Sheet
| Molecular formula: |
C27H36N4O5S |
| Molecular weight: |
528.7 g/mol |
| Purity: |
99%+ |
| Synonyms |
- Ibutamoren
- 159634-47-6
- Ibutamoren [INN]
- UNII-GJ0EGN38UL
- GJ0EGN38UL
|
| Research Applications: |
- Muscle Growth and Fat Loss
- Bone Health
- Improved Sleep
- Cognitive Benefits
- Skin Health
|
MK-677 Research Overview
MK-677 is an orally active growth hormone secretagogue that has been found to significantly increase growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in healthy older adults without serious adverse effects. It has been associated with increased fat-free mass (FFM), body cell mass, and body weight, while not significantly affecting abdominal visceral fat or total fat mass. MK-677 also showed potential in increasing markers of bone formation and resorption, suggesting it could have implications for bone health.
MK-677 (Ibutamoren) and Growth Hormone
MK-677, also known as Ibutamoren, is an orally active growth hormone secretagogue that stimulates the release of growth hormone (GH) in the body. It has been shown to increase GH and insulin-like growth factor 1 (IGF-1) levels in both young and older adults.
In a study with healthy elderly subjects, daily oral administration of MK-677 for two weeks increased GH concentrations in a dose-dependent manner, with a 25 mg/day dose increasing the mean 24-hour GH concentration by 97%. However, the long-term effects of MK-677 on somatic growth in rats were not observed, despite the GH stimulatory effect of MK-677.
MK-677 and Bone Health
MK-677 has been shown to have a positive impact on bone health. In a study with healthy postmenopausal women, daily oral administration of MK-677 for six weeks increased bone mineral content and bone mineral density at the lumbar spine and femoral neck. Another study found that MK-677 administration in rats increased the width of the tibia growth plate, although it did not increase body growth or serum levels of IGF-I.
MK-677 and Sleep Quality
MK-677 has been shown to improve sleep quality in both young and older adults. In a study with healthy young subjects, high-dose MK-677 treatment resulted in an approximately 50% increase in the duration of stage IV sleep and a more than 20% increase in REM sleep compared to placebo. n older adults, treatment with MK-677 was associated with a nearly 50% increase in REM sleep and a decrease in REM latency.
These findings suggest that MK-677 may improve sleep quality and potentially correct the relative hyposomatotropism of senescence.
MK-677 and Skin Health
There is limited research on the direct effects of MK-677 on skin health. However, since MK-677 increases GH and IGF-1 levels, it may indirectly contribute to skin health. GH and IGF-1 play essential roles in skin homeostasis, wound healing, and collagen synthesis.
FAQ
What is MK-677 (Ibutamoren)?
MK-677, also known as Ibutamoren, is a growth hormone secretagogue that promotes the secretion of growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1). It is an orally active, selective, and non-peptide agonist of the ghrelin receptor.
What are the benefits of MK 677?
MK-677 has been reported to offer several benefits, including:
- Increased muscle mass
- Reduced muscle wasting
- Improved bone density
- Enhanced sleep quality
- Potential anti-aging effects
How does MK-677 work?
MK-677 works by signaling the pituitary gland to secrete more growth hormone. It does not cause an increase in the quantity of daily growth hormone pulsations. Unlike peptides, Ibutamoren gives the same benefits but doesn’t cause pituitary desensitization, doesn’t need to be injected, and is cheaper.
Can I buy MK-677 for research purposes?
Yes, you can buy MK-677 for laboratory research use. It’s important to note that all products currently listed on many sites are for research purposes only and not for human consumption.
Can MK-677 improve body composition?
Yes, MK-677 has been shown to significantly increase fat-free mass and body cell mass. It also increases limb fat and body weight.
Can MK-677 be used for growth hormone deficiency?
Yes, MK-677 can be used for the therapeutic treatment of growth hormone deficiency. It inherently upregulates natural growth hormone production.
Can MK-677 increase GH and IGF-1 levels?
Yes, MK-677 significantly increases GH and IGF-1 levels to those of healthy young adults without serious adverse effects.
Can MK-677 be used for Alzheimer’s disease?
While there is ongoing research into the potential benefits of MK-677 for conditions like Alzheimer’s disease, it’s important to note that these products are currently intended for laboratory research use only and not for human consumption.
Can MK-677 increase testosterone levels?
No, MK-677 does not cause any change in the body’s testosterone levels. There are no androgenic side effects.
Can MK-677 improve cholesterol levels?
MK-677 has been shown to decrease low-density lipoprotein cholesterol levels. However, there were no differences in total or high-density lipoprotein cholesterol.
Can MK-677 improve nitrogen retention?
While MK-677 has been shown to increase lean muscle mass, there is currently no specific research indicating that it improves nitrogen retention.
Can MK-677 improve sleep duration and quality?
MK-677 has been reported to improve sleep quality in users. It is believed to enhance the duration of REM sleep, which is the deep sleep phase associated with restorative processes in the body. Adequate sleep is vital for overall health, muscle recovery, and hormonal balance.
Does MK-677 increase lean body mass?
One of the primary benefits of MK-677 is its ability to promote muscle gain and enhance strength. By stimulating the release of GH and insulin-like growth factor 1 (IGF-1), MK-677 helps increase protein synthesis, which is essential for building lean muscle mass.
Does MK-677 increase bone density?
MK-677 has been shown to increase markers of both bone formation and resorption. This means that it stimulates the body to both create new bone and break down old bone, processes that are essential for maintaining healthy bone density.
Is MK-677 available for sale online?
Yes, you can buy MK-677 for sale online from Limitless Life Nootropics for research purposes only. We are the leading online shop to buy peptides and always offer high-quality products, fast shipping and great customer service.
Please note that the information provided above is for educational and informational purposes only and should not be considered medical advice. Always consult with a healthcare professional before using any supplements or making changes to your regimen.
