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N-Acetyl Semax Amidate 10ml Spray (20MG)



10mg – non-lyophilized, 20mg – non-lyophilized, 30mg – non-lyophilized

In Stock


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N-Acetyl Semax Amidate Spray Fact Sheet

Molecular formula: C37H51N9O10S
Molecular weight:
813.9 g/mol
Purity: 98.5%+
  • Semax
  • 80714-61-0
  • ACTH (4-7), Pro-Gly-Pro-
  • Met-Glu-His-Phe-Pro-Gly-Pro
Research Applications:
  • Improved memory
  • Enhanced cognitive function
  • Reduced anxiety
  • Improved sleep patterns
  • Increased motivation
  • Mood enhancement
  • Neuroprotection

N-Acetyl Semax and Neuroprotection

N-Acetyl Semax has been shown to have neuroprotective effects in various animal models of brain injury, including ischemic stroke. The exact mechanisms underlying its neuroprotective effects are not fully understood, but some studies suggest that Semax may modulate the expression of genes involved in the immune response and neurotransmitter systems. In a rat model of cerebral ischemia, Semax was found to suppress the expression of inflammatory genes and activate the expression of neurotransmitter genes [R, R].

In animal models of chronic brain ischemia, Semax has been shown to contribute to the restoration of muscle activity, normalization of coordination, and improvement of emotional behavior. Overall, Semax has demonstrated neuroprotective effects in various animal models of brain injury, but more research is needed to fully understand its mechanisms of action and to determine its potential as a therapeutic agent for neuroprotection in humans [R].

N-Acetyl Semax and Cognitive Function

Research on N-Acetyl Semax has shown its potential in improving cognitive function and providing neuroprotection. Semax is an analog of the adrenocorticotropic hormone (ACTH) fragment and has been found to have significant effects on learning, memory formation, and neuroprotection in both rodents and humans when administered intranasally [R].

One study suggested that the cognitive effects of Semax might be mediated by transthyretin (Ttr), a protein found in the brain. Semax has also been shown to interact with neurotrophic factors and neurotransmitters, which could play a role in its potential effectiveness for treating depression [R].

In a study on rats with chronic brain ischemia, Semax was found to improve cognitive function, particularly when administered in combination with hopantenic acid. Another study demonstrated that Semax increased the expression of brain-derived neurotrophic factor (BDNF) in rat basal forebrain, which could contribute to its cognitive-enhancing effects [R, R].

N-Acetyl Semax and Memory

N-Acetyl Semax has been shown to protect episodic memory function in rodent models. In a study, male Sprague-Dawley rats were treated with Semax daily for four weeks and then exposed to hypoxic conditions. The rats that were treated with Semax showed improved performance in the novel object recognition (NOR) test, suggesting that Semax could prevent memory impairment induced by hypoxia [R].


What is N-Acetyl Semax?

N-Acetyl Semax is a synthetic peptide derived from the natural peptide Semax, which is an analog of the adrenocorticotropic hormone (ACTH)[. It is modified by adding an Acetyl group and an Amidate group to enhance its stability and bioavailability.

What are the potential benefits of N-Acetyl Semax?

N-Acetyl Semax is primarily researched for its potential cognitive and neuroprotective effects. It is believed to interact with various neurotransmitter systems in the brain, including dopamine, serotonin, and norepinephrine, which may contribute to its reported benefits such as improved focus, memory, learning, and mood regulation.

How does N-Acetyl Semax work?

N-Acetyl Semax is thought to work by increasing the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus, and rapidly activating serotonergic and dopaminergic brain systems. It may also act through melanocortin receptors.

What is the difference between Semax and N-Acetyl Semax?

Semax is a synthetic peptide derived from ACTH, while N-Acetyl Semax is a modified version of Semax with an Acetyl group and an Amidate group added to enhance its stability and bioavailability. N-Acetyl Semax is generally considered to be more potent than Semax due to its modified structure.

Where can I buy N-Acetyl Semax for research purposes?

N-Acetyl Semax can be purchased online from reputable biotech suppliers such as Limitless Biotech. Limitless Life offers a wide selection of USA peptides for sale online for scientific research and development purposes.

Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.

What is the stability of N-Acetyl Semax?

The addition of an Acetyl group and an Amidate group to the Semax peptide enhances its stability, making N-Acetyl Semax more resistant to degradation by proteases.

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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