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DSIP: Delta Sleep-Inducing Peptide – 98.5%+ and Pure Versions



5mg lyophilized – 98.5%+, 5mg – non-lyophilized

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DSIP Research Overview

Delta Sleep-Inducing Peptide (DSIP) is a peptide with a molecular weight of 850 daltons. It has the amino acid motif: N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C. DSIP plays various roles, such as endocrine regulation, disease and medicine, and sleep induction. However, the connection between DSIP and sleep is not
fully understood due to the lack of isolation of the DSIP gene, protein, and potential receptor.
Research has been conducted on the effectiveness of DSIP in treating insomnia, pain, and withdrawal. DSIP has shown the ability to counteract opiate receptors, leading to a significant reduction in opioid and alcohol dependence. Clinical trials are currently underway to explore its potential in treating withdrawal syndrome. Additionally, DSIP has been found to alleviate narcolepsy and restore disrupted sleep patterns in certain studies.

DSIP Structure

PubChem CID: 172600
Molecular Formula: C35H49N10O18P
Molecular Weight: 928.8 g/mol
  • delta Sleep-inducing peptide phosphate
  • 70754-23-3
  • (2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-phosphonooxypropanoyl]amino]acetyl]amino]pentanedioic acid
  • Dsip-P
  • delta sleep-inducing peptide, dihydrogen phosphate (ester)

DSIP and Sleep Research

Delta sleep-inducing peptide (DSIP) is a nonapeptide that was discovered in 1977 for its ability to stimulate slow or delta wave sleep. DSIP has been studied for its potential therapeutic effects on sleep and pain. Here are some key findings:

  • A study was conducted to examine the effects of DSIP on sleep in 16 patients with chronic insomnia. The findings revealed that DSIP led to improved sleep efficiency and reduced sleep latency compared to the placebo.
  • In a clinical pilot study, it was found that DSIP showed therapeutic benefits in individuals experiencing chronic and severe pain episodes. The study proposed that DSIP may have a regulatory or “programming” effect on the body’s natural opioid-peptidergic systems, both internally and externally within the brain.
  • Only one study has investigated the effects of DSIP on sleep EEG in normal men and found only minor effects.
  • DSIP possesses various psychophysiological properties in addition to its ability to induce natural sleep.
  • Normal sleep patterns were restored in middle-aged and elderly individuals with chronic insomnia by the end of DSIP administration. These improvements were sustained during the follow-up period.

DSIP and Pain Relief

Research has indicated that DSIP has the potential to effectively reduce pain in patients experiencing chronic and severe pain episodes. In a clinical pilot study, DSIP was given intravenously for five consecutive days, followed by five injections every 48-72 hours. This treatment resulted in a significant reduction in pain levels for six out of seven patients suffering from migraine episodes, vasomotor headaches, chronic tinnitus, and psychogenic pain attacks. Furthermore, DSIP demonstrated pain-reducing effects in headache and other pain syndromes with peptidergic mechanisms.

DSIP and Addiction and Withdrawal

Delta sleep-inducing peptide (DSIP) is a neuropeptide that has been extensively researched for its potential therapeutic applications in treating withdrawal syndromes caused by alcohol and opiates. The basis for this therapeutic use of DSIP comes from various animal studies conducted by Tissot. These studies demonstrated that when DSIP was directly injected into the bulbo-mesencephalo-thalamic recruiting system, it induced slow-wave sleep accompanied by numerous spindles. Importantly, the sleep-inducing effect of DSIP was reversed by Naloxone, suggesting that DSIP may have an agonistic activity on opiate receptors. Therefore, DSIP holds promise as a potential treatment for withdrawal syndromes.
DSIP was given intravenously to 107 inpatients who showed symptoms of alcohol or opiate withdrawal. The doctors and nurses evaluated the effects of the treatment. About 13% of patients in the first group and 22% in the second group were unable to complete the evaluation. In 97% of opiate addicts and 87% of alcoholics, the clinical symptoms improved or disappeared after receiving DSIP. However, anxiety took longer to decrease. Overall, opiate addicts required more DSIP injections and had a longer course of clinical symptoms compared to alcoholics. Most patients tolerated the DSIP treatment well, although a few reported experiencing headaches.

DSIP and Cancer

A mouse study found that DSIP has a protective effect against aging and cancer in mice. When mice were treated with a preparation called Deltaran, which contains DSIP, the overall occurrence of tumors decreased significantly (by 2.6 times), particularly in the form of mammary carcinomas and leukemias, compared to the control group.


What Is DSIP (Delta Sleep-Inducing Peptide)?

Delta Sleep-Inducing Peptide (DSIP) is a neuropeptide known for its sleep-promoting and stress-reducing effects. It was initially discovered in the cerebral venous blood of sleeping rabbits. DSIP is a naturally occurring substance that is produced in the hypothalamus and acts on various sites in the brainstem. It specifically enhances a type of sleep characterized by an increase in the delta rhythm of the EEG. Unlike sedatives, DSIP is described as a sleep-promoting substance with the ability to modulate sleep and wake functions, particularly in disrupted sleep conditions. It is not a sedative that needs to be taken right before bedtime. DSIP has been extensively studied for its potential therapeutic benefits in addressing sleep-related issues.

What are the Benefits of DSIP?

DSIP, or Delta Sleep-Inducing Peptide, is a neuropeptide that has various benefits for sleep and overall well-being. It can regulate sleeping patterns, shorten the time it takes to fall asleep, and extend the duration and quality of sleep. By binding to specific receptors in the brain that regulate sleep and relaxation, DSIP helps relax the body and mind, potentially reducing insomnia and increasing deep sleep. Additionally, it may reduce anxiety, depression, and fatigue, while improving memory and alertness during the day.

Some of the benefits of DSIP include improved sleep quality and duration, reduced stress, improved alertness, improved mood, and reduced chronic pain. In addition to its effects on sleep, DSIP has been studied for its potential interactions with neurotransmitters like dopamine and serotonin. This peptide may have immune-boosting properties, act as an antioxidant and anti-inflammatory, help with anxiety and depression, regulate pain, blood pressure, and circadian rhythm. These additional uses make DSIP a versatile compound with potential benefits beyond sleep regulation.

Where to Buy DSIP Peptide?

You can buy peptides like DSIP (Delta Sleep Inducing Peptide) online from certified vendors of research peptides such as Limitless Life Nootropics. Make sure to choose a reputable source to ensure the quality of the product.

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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