Tesofensine was first investigated for its potential to treat Parkinson’s disease and Alzheimer’s because it blocks the reuptake of serotonin, noradrenaline, and dopamine. Unfortunately, the test volunteers started dropping too much weight, therefore it was unable to fully explore its potential for these indications. Since then, tesofensine’s appetite-suppressing properties have been investigated for their potential as a treatment for obesity. This chemical compound has been shown to be more effective than other weight-loss drugs because of the indirect stimulation it provides to the cholinergic system. The brain’s transmission of three monoaminergic neurotransmitters is boosted by tesofensine (TE).
Serotonin, norepinephrine, and dopamine are neurotransmitters that have been associated with weight control and mental health issues including depression and obesity. Results from a phase 2b clinical research showed that after 6 months of use, participants lost an average of 25 pounds. Recent studies have indicated that TE has a significant impact on feelings of hunger while having just a little impact on metabolic rate. In other cases, both effects may be responsible for the dramatic weight loss.
PubChem CID: 11370864
Molecular Formula: C17H23Cl2NO
Molecular Weight: 328.3
CAS Number: 195875-84-4
Synonyms: Tesofensine, 195875-84-4, NS-2330, Tesofensine [INN], NS 2330
Tesofensine and Weight Loss
Tesofensine has been studied for its potential to promote weight loss. Here are some key findings:
- In a study of 203 patients, tesofensine resulted in a dose-dependent weight loss of 6.5-12% after 24 weeks of treatment.
- In a randomized, double-blind, placebo-controlled trial, tesofensine at doses of 0.25 mg, 0.5 mg, and 1.0 mg induced a mean weight loss of 4.5%, 9.2%, and 10.6%, respectively, greater than diet and placebo.
- Tesofensine has been shown to significantly reduce hunger and appetite measures compared to placebo.
- A phase II study showed that tesofensine is very effective in producing weight loss in obese patients over 6 months.
- Tesofensine 0.5 mg produces at least twice the weight loss of other drugs like sibutramine, and has no effect on blood pressure.
- Tesofensine reduces appetite by stimulating the cholinergic system.
Tesofensine for Depression
Tesofensine enhances the production of brain chemicals like dopamine, norepinephrine, and serotonin, which are linked to mood regulation, motivation, reward system, cognitive abilities, and reproductive behaviors. Research indicates that prolonged use of tesofensine has a positive impact on treating depression and improving overall mood.