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MOTS-c Peptide Research

MOTS–c is a 16-amino-acid peptide encoded in the mitochondrial genome. MOTS–c targets muscle and regulates metabolism via the folate-purine-AMPK pathway. MOTS–c mediates mitochondrial regulation of insulin and metabolic homeostasis.

MOTS-c Structure

PubChem CID: 146675088
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.6
CAS Number: 1627580-64-6
Synonyms: UNII-A5CV6JFB78, 1627580-64-6, A5CV6JFB78, Mitochondria-derived peptide mots-c

MOTS-c and Metabolism

MOTS-c plays a vital role in regulating metabolic functions throughout the body, particularly in glucose utilization for energy production. Its impact on skeletal muscle and glucose metabolism has far-reaching implications for obesity, diabetes, exercise, and longevity. Notably, MOTS-c exhibits close associations with amino acid, carbohydrate, and lipid metabolism.

Key findings reveal that MOTS-c promotes metabolic homeostasis, reducing obesity and insulin resistance. It enhances cellular glucose flux, leading to reduced glucose levels in mice on a normal diet.

Furthermore, MOTS-c improves systemic insulin sensitivity, as evidenced by enhanced glucose clearance in glucose tolerance tests and hyperinsulin-orthoglycemic clamping studies. In post-menopausal mice, MOTS-c administration activates brown fat, lowers inflammatory markers in white adipose tissue, decreases fatty acid levels in serum and liver, and limits weight gain. AMPK activation by MOTS-c minimizes fat deposition, restores energy balance, and improves insulin sensitivity.

Additionally, MOTS-c prevents fat accumulation in mice by modulating sphingolipid metabolism pathways. Overall, MOTS-c exerts regulatory effects on metabolic flexibility, homeostasis, mitochondrial energy regulation, and protection against age and diet-related metabolic disorders.


MOTS-c and Insulin Sensitivity

MOTS-c has been extensively studied and demonstrated to augment insulin sensitivity through the inhibition of the folate cycle and its tethered de novo purine biosynthesis, consequently instigating AMPK activation.

Additionally, MOTS-c exhibits a protective effect against obesity and fatty liver by increasing beta-oxidation and glucose uptake.

Notably, this peptide is activated in response to stress and exercise, while its expression diminishes with advancing age. These findings suggest that MOTS-c holds significant potential in promoting healthy aging and averting metabolic diseases.


MOTS-c and Osteoporosis

Studies indicate that MOTS-c could potentially exert a positive influence on osteoporosis by stimulating the synthesis of type I collagen in osteoblasts via the TGF-β/SMAD signaling pathway. Type I collagen serves as a crucial constituent of the bone matrix, contributing to bone strength and overall quality.

Furthermore, MOTS-c may enhance bone cell differentiation and alleviate symptoms associated with osteoporosis by modulating genes involved in stress adaptation and metabolism. As a result, MOTS-c shows promise in the prevention and treatment of osteoporosis through its capacity to enhance bone formation and mitigate bone loss.



What is MOTS-c?

MOTS-c is a mitochondrial-derived peptide specifically encoded by the 12S rRNA region of the mitochondrial genome. It serves as a regulator of metabolic functions across the entire body, with a notable role in the conversion of glucose into usable energy. As a relatively recent discovery, MOTS-c holds promise in unraveling the intricate mechanisms underlying metabolic processes and their implications for human health.

How Does MOTS-c Work?

MOTS-c exerts its physiological effects by modulating metabolic processes throughout the body, including the conversion of glucose into usable energy. It specifically targets muscle tissues and regulates metabolism through the folate-purine-AMPK pathway. This pathway plays a crucial role in mediating the mitochondrial control of insulin signaling and maintaining metabolic homeostasis.

What are the Benefits of MOTS-c?

MOTS-c has a long list of possible benefits, including:

  • Enhancing cellular-level physical function and exercise capacity.
  • Increasing metabolic homeostasis, thereby reducing obesity and insulin resistance.
  • Providing protection against age-related and diet-related metabolic alterations.
  • Promoting fatty acid metabolism within the liver.
  • Facilitating metabolic flexibility and homeostasis.
  • Regulating mitochondrial energy production.
  • Assisting in the regulation of various metabolic functions throughout the body, including the conversion of glucose into usable energy.
  • Enhancing insulin sensitivity and promoting glucose uptake in myocytes (muscle cells).
  • Mitigating fat accumulation by modulating the pathways involved in sphingolipid metabolism.
  • Supporting resistance to metabolic stress.
  • Improving glucose regulation.
  • Strengthening the immune system.
  • Enhancing endurance.
  • Increasing energy levels through the upregulation of mitochondria.
  • Preventing osteoporosis by stimulating osteoblast activity.

Where to Buy MOTS-c

Limitless Life Nootropics is the leading, most reliable online source for purchasing MOTS-c. Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all peptides available for sale.

This meticulous process ensures that customers consistently receive pharmaceutical-grade products of the utmost purity. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.

Does MOTS-c Help with Bodybuilding?

MOTS-c exhibits potential benefits in the realm of bodybuilding by enhancing physical function, improving cellular-level exercise capacity, and promoting muscle homeostasis. Its primary focus is on targeting muscle tissue and regulating metabolism through the folate-purine-AMPK pathway.

Research findings indicate that MOTS-c treatment resulted in significant improvements in running endurance and distance for middle-aged and old mice compared to untreated mice. Notably, the performance of old mice even surpassed that of untreated middle-aged mice. These outcomes suggest a potential mechanism of physical re-programming rather than mere rejuvenation, indicating MOTS-c’s ability to enhance exercise capacity at a cellular level.

MOTS-c may also provide a boost to metabolism and contribute to improved muscle development, weight loss and exercise performance. Additionally, it aids in the regulation of mitochondrial energy and shows promise in enhancing muscle function and promoting bone metabolism.

However, it is crucial to acknowledge that the benefits of MOTS-c for bodybuilding are still under investigation and further research is necessary to comprehensively understand its impact on muscle growth and development.


Certificate of Analysis for MOTS-C
Certificate of Analysis for MOTS-C

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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