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ACTOVEGIN ® 5ml Solution (200mg)

Original price was: $26.99.Current price is: $15.99.

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5ml Glass Ampoule

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Research

This Actovegin concentrate is 5ml total volume 40mg per ml and has 200mg total Actovegin present in the concentration. The solutions base contains 134 mg of sodium chloride.

Actovegin Research

Actovegin is a deproteinized hemodialysate of calf’s blood, which is postulated to improve cellular uptake and utilization of glucose and oxygen. It is a highly filtered extract that enhances aerobic oxidation in mammals, thereby improving the absorption of glucose and oxygen. Actovegin has been used for several decades in countries of Central Asia, East Asia, Russia, and some European countries to treat patients with various neurological conditions, vascular disorders, and ischemic stroke.

Actovegin and Wound Healing

Research indicates that Actovegin has a reparative effect on wounds, contributing to the healing process. In a study comparing the effects of different gels on wound healing in rats, Actovegin was found to have a pronounced reparative effect. The study assessed wound healing by studying the physicomechanical properties of the wound, determining the concentration of hydroxyproline, and calculating the ratio of collagen types 1 and 3. The results showed that Actovegin had a greater effect on wound healing than the control and Contractubex [R].

Another study compared the wound healing effects of a low molecular weight fraction of cattle cord blood and Actovegin on skin cryolesions in rats. Both treatments accelerated the normalization of clinical blood parameters and showed a pronounced wound healing effect, manifested in accelerated reparation and improved trophicity in the injured area due to hypervascularization and prevention of sclerotic processes [R].

A third study compared the effects of Actovegin and collagen on skin wound healing in mature rats. The study found that both treatments were effective, but the wound healing patterns and rates were different, which might be due to different mechanisms of action of the drugs [R].

Actovegin and Neuroprotection

Actovegin has been the subject of various studies exploring its potential in neuroprotection and tissue regeneration. Neuroprotection refers to the preservation of brain structure and function, often measured behaviorally in clinical settings. Actovegin has been investigated for its potential in this area, particularly in the context of ischemic stroke and traumatic brain injury (TBI).

In a study involving patients with unresponsive wakefulness syndrome (UWS) after severe TBI, Actovegin was part of a neuroprotective treatment regimen that also included other substances like Cerebrolysin, pyritinol, and L-carnitine. The study found that patients receiving this treatment recovered more rapidly from UWS than controls, suggesting that long-term neuroprotection may be key for patients to overcome UWS after severe TBI [R].

Actovegin and Tissue Regeneration

Actovegin has also been studied for its role in tissue regeneration. In a study involving mandibular bone tissue regeneration, Actovegin was used in combination with various osteoplastic materials. The study found that Actovegin, when used in conjunction with these materials, effectively stimulated bone tissue regeneration [R].

Another study compared the effects of Actovegin and a low molecular weight cattle cord blood fraction on tissue regeneration after skin cryoablation in rats. Both treatments showed a pronounced wound healing effect, manifested in accelerated reparation and improved trophicity in the injured area [R].

FAQ

What is Actovegin?

Actovegin is a highly filtered extract obtained from calf blood that enhances aerobic oxidation in mammals. It has been used to treat various neurological conditions, vascular disorders, and ischemic stroke.

How Does Actovegin Work?

Actovegin improves the absorption of glucose and oxygen uptake in tissue, which may enhance physical performance and stamina. It is believed to function by enhancing cellular metabolism and respiration, activating the aerobic routes of energy metabolism, and improving the functional state of the central nervous system.

What are the Studied Benefits of Actovegin?

Actovegin has been shown to have wound healing, neuroprotective, and antioxidant properties, as well as the ability to enhance glucose uptake and oxygen consumption. It has been used in various clinical settings, including the treatment of blood circulation and trophic disturbances in the brain, peripheral blood circulation impairment, dermal transplants, and acute and chronic wounds. Studies have also suggested that Actovegin may improve muscle repair and recovery in athletes. 

Does Actovegin improve blood flow?

Actovegin has been shown to improve blood flow in certain conditions. It has demonstrated positive effects on the development of collateral blood flow in patients with distal occlusion of the lower limbs. Actovegin’s effects on microcirculation include increased capillary blood flow speed, decreased pericapillary space, and reduced myogenic tone of precapillary arterioles and capillary sphincters [R].

Has Actovegin been used to treat brain injury?

Actovegin has been used to treat brain injuries of mild and moderate severity. In a study involving 68 patients with various traumatic brain injuries, Actovegin was administered in addition to standard therapy. The results showed that Actovegin improved the course of brain injuries, promoting earlier compensation of disturbed functions and shortening treatment duration. Actovegin has also been used in the complex treatment of patients with severe cerebral trauma [R].

What effect does Actovegin have on metabolic processes?

Actovegin® has been shown to have several effects on metabolic processes. It is believed to improve the transport and utilization of glucose and oxygen, which can lead to enhanced aerobic oxidation. This process provides cells with more energy and potentially enhances their function [R].

Has Actovegin been used in the context of sports injuries?

Actovegin has been used for the treatment of sports muscle injuries. The drug has been shown to improve intrinsic mitochondrial respiratory capacity in injured human skeletal muscle fibers, which could explain its reported ergogenic properties. This means that muscle cells are able to burn more oxygen faster after being exposed to Actovegin [R].

Research suggests that Actovegin is a non-ergogenic, safe, and potentially beneficial biological drug for the treatment of sports injuries. However, further research is needed to fully understand the effects of Actovegin in elite athletes and its potential role in sports injuries [R].

Has Actovegin® been studied for help with diabetic polyneuropathy?

A multicenter, randomized, double-blind trial involving 569 type 2 diabetic patients with symptomatic diabetic peripheral polyneuropathy found that treatment with Actovegin® intravenously for 20 days, followed by oral treatment for 140 days, was safe and effective in improving neuropathic symptoms, vibration perception threshold (VPT), sensory nerve function, and mental health [R].

Another study compared the efficacy of Actovegin® combined with rehabilitation versus rehabilitation alone in painful diabetic neuropathy. The study concluded that the combination of Actovegin® and rehabilitation was more efficient than rehabilitation alone, suggesting a neuroprotective activity of the drug [R].

What is the efficacy of Actovegin in post-stroke cognitive impairment?

Actovegin has been studied for its potential benefits in post-stroke cognitive impairment (PSCI). The ARTEMIDA trial, a 12-month, randomized, multicenter, double-blind, placebo-controlled study, found that Actovegin had a beneficial effect on cognitive outcomes in patients with PSCI. The study reported a statistically significant improvement in the Alzheimer’s Disease Assessment Scale, cognitive subscale, extended version (ADAS-cog+) for patients treated with Actovegin compared to those receiving a placebo, with an estimated treatment difference of -2.3 (95% confidence interval, -3.9 to -0.7; P=0.005) [R].

What are the potential future concepts for Actovegin?

Future concepts for Actovegin could potentially include a wider use in the treatment of pathological conditions involving energy metabolism, especially in neuronal tissues. Other possible areas include sports medicine, cognitive impairment treatment, and addressing ischemia in various medical conditions.

Where to Buy Actovegin® Online?

Actovegin can be purchased online from reputable biotech suppliers such as Limitless Life Biotech. Limitless offers a wide selection of USA peptides for sale online for scientific research purposes.

Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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