5-amino-1MQ inhibits nicotinamide N-methyltransferase activity (NNMT). 5-amino-1MQ blocks NNMT to raise NAD+, a coenzyme important to cellular metabolism, raising metabolic rate and activating sirtuin-1 (SIRT1). SIRT1 is the “longevity gene” since in studies it reduces the risk of diabetes, obesity, metabolic syndrome, atherosclerosis, renal disease, liver disease, neurodegeneration, and cancer.
NMN (Nicotinamide mononucleotide) is a precursor to the cofactor NADH, which helps enzymes critical to metabolism and DNA repair function properly. Research has shown NMN to reduce age-associated body weight gain, improve energy metabolism, improve insulin sensitivity and plasma lipid profile, enhance eye function, and other pathophysiologies.
JBSNF-000088 decreases MNA levels, increases insulin sensitivity, and reduces body weight in animal models of metabolic illness. In mice with HFD-induced obesity, JBSNF-000088 reduced body weight, enhanced insulin sensitivity, and corrected glucose tolerance.
These three substances have an effect on everything from the metabolism of energy to the functioning of cells as well as the aging process. They do this largely via influencing the concentration of NAD, as well as the expression of GLUT-4 receptors, the activity of the NNMT enzyme, and the creation of chemicals known as sirtuins. Together, these molecules combine to increase cellular metabolism, which in turn helps with weight reduction and glucose management. This is accomplished by elevating cellular levels of NAD while simultaneously lowering the activity of NNMT. The synergy between these chemicals has other advantages, one of which is evident in the process of cellular aging, where it helps stem cells to survive and flourish when there are greater amounts of NAD. This results in an increased pool of healthy cells that can rapidly replace worn out or damaged cells, leading to greater tissue function and a reduction in the symptoms of aging. It is believed that by combining these three substances, it will be feasible to bring about significant improvements in energy metabolism while at the same time enhancing the anti-aging, anti-inflammatory, and anti-apoptosis action that is present in cells.
Molecular Formula: C10H11N2+
Chemical Formula: C11H15N2O8P
- Bogan KL, Brenner C (2008). “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition”. Annual Review of Nutrition. 28: 115–30. doi:10.1146/annurev.nutr.28.061807.155443. PMID 18429699.
- Grozio, A; Mills, KF; Yoshino, J; Bruzzone, S; Sociali, G; Tokizane, K; Lei, HC; Cunningham, R; Sasaki, Y; Migaud, ME; Imai, SI (January 2019). “Slc12a8 is a nicotinamide mononucleotide transporter”. Nature Metabolism. 1 (1): 47–57. doi:10.1038/s42255-018-0009-4. PMC 6530925. PMID 31131364.
- Schmidt, MS; Brenner, C (July 2019). “Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter”. Nature Metabolism. 1 (7): 660–661. doi:10.1038/s42255-019-0085-0. PMID 32694648. S2CID 203899191.
- Chini, CCS; Zeidler, JD; Kashyap, S; Warner, G; Chini, EN (1 June 2021). “Evolving concepts in NAD+ metabolism”. Cell Metabolism. 33 (6): 1076–1087. doi:10.1016/j.cmet.2021.04.003. PMC 8172449. PMID 33930322.
- Brazill JM, Li C, Zhu Y, Zhai RG (June 2017). “+ synthase… It’s a chaperone… It’s a neuroprotector”. Current Opinion in Genetics & Development. 44: 156–162. doi:10.1016/j.gde.2017.03.014. PMC 5515290. PMID 28445802.
- Mills, Kathryn F.; Yoshida, Shohei; Stein, Liana R.; Grozio, Alessia; Kubota, Shunsuke; Sasaki, Yo; Redpath, Philip; Migaud, Marie E.; Apte, Rajendra S.; Uchida, Koji; Yoshino, Jun; Imai, Shin-Ichiro (13 December 2016). “Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice”. Cell Metabolism. 24 (6): 795–806. doi:10.1016/j.cmet.2016.09.013. PMC 5668137. PMID 28068222.
- Stipp D (March 11, 2015). “Beyond Resveratrol: The Anti-Aging NAD Fad”. Scientific American Blog Network.
- Irie, Junichiro; Inagaki, Emi; Fujita, Masataka; Nakaya, Hideaki; Mitsuishi, Masanori; Yamaguchi, Shintaro; Yamashita, Kazuya; Shigaki, Shuhei; Ono, Takashi; Yukioka, Hideo; Okano, Hideyuki (2020). “Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men”. Endocrine Journal. 67 (2): 153–160. doi:10.1507/endocrj.EJ19-0313. ISSN 0918-8959. PMID 31685720.
- Yoshino, M; Yoshino, J; Kayser, BD; Patti, GJ; Franczyk, MP; Mills, KF; Sindelar, M; Pietka, T; Patterson, BW; Imai, SI; Klein, S (11 June 2021). “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women”. Science. 372 (6547): 1224–1229. Bibcode:2021Sci…372.1224Y. doi:10.1126/science.abe9985. PMC 8550608. PMID 33888596.
- “”Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study””.
- Fletcher RS, Lavery GG (October 2018). “The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism”. Journal of Molecular Endocrinology. 61 (3): R107–R121. doi:10.1530/JME-18-0085. PMC 6145238. PMID 30307159.
- Cambronne XA, Kraus WL (October 2020). “+ Synthesis and Functions in Mammalian Cells”. Trends in Biochemical Sciences. 45 (10): 858–873. doi:10.1016/j.tibs.2020.05.010. PMC 7502477. PMID 32595066.
- “NMN vs NR: The Differences Between These 2 NAD+ Precursors”. www.nmn.com. Retrieved 2021-01-11.
- Tarragó, MG; Chini, CCS; Kanamori, KS; Warner, GM; Caride, A; de Oliveira, GC; Rud, M; Samani, A; Hein, KZ; Huang, R; Jurk, D; Cho, DS; Boslett, JJ; Miller, JD; Zweier, JL; Passos, JF; Doles, JD; Becherer, DJ; Chini, EN (1 May 2018). “A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline”. Cell Metabolism. 27 (5): 1081–1095.e10. doi:10.1016/j.cmet.2018.03.016. PMC 5935140. PMID 29719225.
- Ryan, Finn (2016-12-06). “5 Anti-Aging Food Types You Should Already Be Eating”. Bicycling. Retrieved 2022-01-20.
- “Scientists identify new fuel-delivery route for cells”. Washington University School of Medicine in St. Louis. 2019-01-07. Retrieved 2022-01-20.
Molecular Formula: C7H8N2O2