Quercetin 98%

$11.99$19.99

I’m sure you noticed credit and debit card processing removed from site. We were the last nootropics company with a major US processor. While we are waiting the paperwork to go through for offshore processing, you can still order with a credit or debit card. Place your order and then screenshot it and send it to limitlesslifenootropics@protonmail.com. We will email an invoice that you can pay with any debit or credit card. Invoice comes from a major American processor, but there is no plug in available with our web host. Simply click view invoice, then pay invoice and it will take you to a secure payment processor where you can pay with debit or credit card including American Express or bank transfer. Or feel free to call 1-800-782-1905 and we can take your order over the phone and run your card manually. If you can’t screenshot send us your order through our contact form. We hope to keep your business during this transition! Thanks for sticking with us! Be sure to check out Google reviews. We are rated 5 stars.

Clear
Compare
SKU: N/A Category:

Description

From Wikipedia:

Pharmacology[edit]

Pharmacokinetics[edit]

The oral bioavailability of quercetin in humans is low and highly variable (0-50%) and is rapidly cleared (elimination half-life of 1–2 hours after IV injection).[26] Following dietary ingestion, quercetin undergoes rapid and extensive metabolism that makes the biological effects presumed from in vitro studies unlikely to apply in vivo.[27][28]

Metabolism[edit]

In rats, quercetin did not undergo any significant phase I metabolism.[29] In contrast, quercetin did undergo extensive phase II (conjugation) to produce metabolites that are more polar than the parent substance and hence are more rapidly excreted from the body. The meta-hydroxyl group of catechol is methylated by catechol-O-methyltransferase. Four of the five hydroxyl groups of quercetin are glucuronidated by UDP-glucuronosyltransferase. The exception is the 5-hydroxyl group of the flavonoid ring which generally does not undergo glucuronidation. The major metabolites of orally absorbed quercetin are quercetin-3-glucuronide, 3′-methylquercetin-3-glucuronide, and quercetin-3′-sulfate.[29][30]

In vitro pharmacology[edit]

Quercetin has been reported to inhibit the oxidation of other molecules and hence is classified as an antioxidant.[27][30] Quercetin contains a polyphenolic chemical substructure that stops oxidation by acting as a scavenger of free radicals that are responsible for oxidative chain reactions.[31]

Quercetin also activates or inhibits the activities of a number of proteins.[32] For example, quercetin is a non-specific protein kinase enzyme inhibitor.[27][30] Quercetin has also been reported to have estrogenic (female sex hormone like) activities by activating estrogen receptors. Quercetin activates both estrogen receptor alpha (ERα) and beta (ERβ)[33]with binding IC50s of 1015 nM and 113 nM respectively. Hence quercetin is somewhat ERβ selective (9 fold) and is roughly two to three orders of magnitude less potent than the endogenous estrogenic hormone 17β-estradiol.[34][35] In human breast cancer cell lines, quercetin has also been found to act as an agonist of the G protein-coupled estrogen receptor (GPER).[36][37]

Reviews

There are no reviews yet.

Be the first to review “Quercetin 98%”

Your email address will not be published. Required fields are marked *