N-Acetyl Semax Amidate 30mg / N-Acetyl Selank Amidate 30mg Blend

$120.00

This is a dry Blend packaged in a 10ml amber vial without fillers.

This blend contains 30mg of N-Acetyl Selank Amidate and 30mg of N-Acetyl Semax Amidate.

We send (1) 10 ml nasal sprayer, filled with deionized water, with this product.

Legal Disclaimer:

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. Only in vitro testing should be done using the products that may be purchased from this website. Research that is carried out in vitro takes place outside of the human body. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

 

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N-Acetyl Semax Amidate 30mg / N-Acetyl Selank Amidate 30mg Blend

N-Acetyl Semax Amidate

Semax.png

Molecular Formula:C37H51N9O10S

CAS: 80714-61-0

Sequence: MEHFPGP

N-Acetyl Semax Amidate is the newest analog of Semax. It crosses the blood brain barrier easier than the original form of Semax and therefore is more potent by weight.  Upon receipt, use included medicine syringe to remove solution from the spray bottle and transfer into the amber container containing peptide, shake gently and let dissolve. This should take around 30 seconds. Then transfer back into the spray bottle and immediately refrigerate. Product should remain in refrigerator when not in use.

Contents: N-Acetyl Semax Amidate, Verified by HPLC to exceed 99.30% purity.

L-Methionyl-L-α-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L-proline, (Pro8,Gly9,Pro10)ACTH-(4-10)

Status of N-Acetyl Semax Amidate nasal spray

N-acetyl Semax spray is a medication in Russia and Eastern Europe for stroke and other types of brain injury.  In the US, it is an unregulated substance.

Research Studies

  1. Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats.
  2. Changes in Sympathetic Innervation of Rat Caudal Artery in Experimental Myocardial Infarction. Effect of Semax Peptide.
  3. Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.
  4. Semax prevents learning and memory inhibition by heavy metals.
  5. [EFFECT OF PEPTIDE SEMAX ON SYNAPTIC ACTIVITY AND SHORT-TERM PLASTICITY OF GLUTAMATERGIC SYNAPSES OF CO-CULTURED DORSAL ROOT GANGLION AND DORSAL HORN NEURONS].
  6. The action of the peptide drug Semax on the currents of AMPA receptors of rat cerebellar Purkinje cells.
  7. [Opposite Semax influence on conditioning and functional disturbances of avoidance responses in rats].
  8. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.
  9. Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats.
  10. [The effect of semax and its C-end peptide PGP on Vegfa gene expression in the rat brain during incomplete global ischemia].
  11. Study of proteolysis of Semax analogues with different N-terminal amino acids by carboxypeptidases.
  12. Semax corrects brain dysfunction caused by prenatal introduction of valproic acid.
  13. Semax prevents functional impairments of avoidance response in rats.
  14. Antistress effect of Semax in the course of recovery of spleen lymphoid structures after the stress in rats with different behavioral activity.
  15. Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.
  16. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.
  17. [Effect of semax and mexidol on brain ischemia models in rats].
  18. Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity.
  19. Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax.
  20. [Study of the efficacy of semax in global cerebral ischemia in vivo].

 

N-Acetyl Selank Amidate

 

Selank.png

Molecular Formula:C33H57N11O9

CAS: 129954-34-3

Sequence: TKPRPGP

 

N-acetyl Selank amidate is the newest analog of Selank. It crosses the blood brain barrier easier than the original form of Selank and therefore is more potent by weight. Spray bottle will be included.

  1.  Uchakina, O. N.; Uchakin, P. N.; Miasoedov, N. F.; Andreeva, L. A.; Shcherbenko, V. E.; Mezentseva, M. V.; Gabaeva, M. V.; Sokolov, O. U.; Zozulia, A. A.; Ershov, F. I. (2008). “Immunomodulatory effects of selank in patients with anxiety-asthenic disorders”. Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova108 (5): 71–75. PMID 18577961.
  2. ^ Narkevich, VB; Kudrin, VS; Klodt, PM; Pokrovskiĭ, AA; Kozlovskaia, MM; Maĭskiĭ, AI; Raevskiĭ, KS (2008). “Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study”. Eksperimental’naia i Klinicheskaia Farmakologiia71 (5): 8–12. PMID 19093364.
  3. ^ Semenova, T. P.; Kozlovskiĭ, I. I.; Zakharova, N. M.; Kozlovskaia, M. M. (2010). “Experimental optimization of learning and memory processes by selank”. Eksperimental’naia i Klinicheskaia Farmakologiia73 (8): 2–5. PMID 20919548.
  4. ^ Semenova, T. P.; Kozlovskiĭ, I. I.; Zakharova, N. M.; Kozlovskaia, M. M. (2009). “Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA”. Eksperimental’naia i Klinicheskaia Farmakologiia72 (4): 6–8. PMID 19803361.
  5. ^ Inozemtseva, LS; Karpenko, EA; Dolotov, OV; Levitskaya, NG; Kamensky, AA; Andreeva, LA; Grivennikov, IA (2008). “Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo”. Doklady Biological Sciences421: 241–3. doi:10.1134/s0012496608040066PMID 18841804S2CID 40709909.
  6. ^ Kost NV; Sokolov OIu; Gabaeva MV; et al. (2001). “Semax and selank inhibit the enkephalin-degrading enzymes from human serum”. Bioorg. Khim. (in Russian). 27 (3): 180–3. doi:10.1023/A:1011373002885PMID 11443939S2CID 26029820.
  7. ^ Solov’ev VB, Gengin MT, Sollertinskaia TN, Latynova IV, Zhivaeva LV (2012). “[Effect of selank on the main carboxypeptidases in the rat nervous tissue]”. Zh. Evol. Biokhim. Fiziol. (in Russian). 48 (3): 254–7. PMID 22827026.
  8. ^ Sarkisova KIu, Kozlovskiĭ II, Kozlovskaia MM (2008). “[Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice]”. Zh Vyssh Nerv Deiat Im I P Pavlova (in Russian). 58 (2): 226–37. PMID 18661785.
  9. ^ Institute of Molecular Genetics: Translation of Archived 2011-07-22 at the Wayback Machine

Related Nootropics

  1. noopept
  2. phenotropil
  3. selank
  4. bromantane
  5. phenibut
  6. semax
  7. N-Acetyl Semax
  8. N-Acetyl Selank
  9. N-Acetyl Semax Amidate
  10. N-Acetyl Selank Amidate

 

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