Research
KPV Peptide Overview
KPV is a tripeptide (Lysine-Proline-Valine) that possesses potent anti-inflammatory properties. It is a naturally occurring tripeptide that has been shown to attenuate the inflammatory responses of colonic cells. KPV is present in the hormone alpha-MSH and is utilized for managing inflammation, promoting gut health, and addressing conditions like Inflammatory Bowel Disease (IBD) and colon cancer. It has been shown to inhibit the activation of NF-kappaB and MAP kinase inflammatory signaling pathways, and reduce pro-inflammatory cytokine secretion.
The peptide KPV can enter cells through an unregulated transporter during inflammation. Research suggests that KPV could be used to treat or prevent inflammatory conditions. Inside cells, KPV works to reduce inflammation by deactivating inflammatory pathways. It can also enter the cell nucleus and inhibit the interaction of inflammatory substances and molecules.
Structure of KPV
PubChem CID: 125672
Molecular Formula:Â C16H30N4O4
Molecular Weight: 342.43Â g/mol
Synonyms:
- Lys-pro-val
- 67727-97-3
- L-Valine, N-(1-L-lysyl-L-prolyl)-
- Msh (11-13)
- L-Lysyl-L-prolyl-L-valine
KPV and Inflammation
KPV is a tripeptide (Lys-Pro-Val) that has anti-inflammatory properties. The mechanisms of action of KPV are not yet fully understood, but it has been shown to inhibit the activation of NF-kappaB and MAP kinase inflammatory signaling pathways, and reduce pro-inflammatory cytokine secretion.
KPV functions through PepT1, a transporter for dipeptides and tripeptides that is typically found in the small intestine and is upregulated in the colon during inflammatory bowel disease (IBD). KPV has been found to have significant anti-inflammatory effects in murine models of colitis. In these studies, KPV treatment led to earlier recovery and significantly stronger regain of body weight, reduced inflammatory infiltrates, and reduced myeloperoxidase (MPO) activity in colonic tissue.
KPV has been suggested as an interesting therapeutic option for the treatment of IBD. KPV has also been shown to decrease the inflammatory response of colonic epithelial cells to inflammatory stimulation. Hyaluronic acid-functionalized nanoparticles have been proven effective in relieving ulcerative colitis through targeted delivery of KPV.
References:
https://pubmed.ncbi.nlm.nih.gov/18061177/
https://pubmed.ncbi.nlm.nih.gov/18092346/
https://academic.oup.com/ibdjournal/article/14/3/324/4653598?login=false
https://www.sciencedirect.com/science/article/abs/pii/S0016508507018525
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdfExtended/S1525-0016(16)45431-6
KPV and Gut Health
KPV has been extensively studied for its benefits in overall gut health and its applications in the treatment of inflammatory bowel disease (IBD) and colon cancer.
KPV has anti-inflammatory and anti-microbial properties, and it can help with healing wounds and injuries. It can also reduce inflammation in colitis by inhibiting proinflammatory cytokine synthesis and secretion. KPV has the ability to directly interact with immune cells, leading to a decrease in inflammation.
KPV can also support the healing of the mucosal lining of the gut, which helps with the condition of ulcerative colitis.
References:
