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Adrafanil is a member of the eugeroic class [ ]of drugs. Their name stems from the Greek for “good stimulants.” Adrafinil was discovered in the 70’s. Initially it was used as a narcoleptic treatment. Adrafinil passes through the liver to create a metabolite known as modafinil. Modafinil has been used by militaries worldwide due to it’s unique ability to increase productivity, wakefulness and efficiency without the side effects of traditional central nervous system stimulants. ]
Adrafnil’s exact mechanisms of action are not fully understood, however it is thought to involve elevation of hypothalamic (hypothalamus is where new memories are recorded) histamine. Histamine and epinephrine are primary components to vigilance and alertness. In addition it also seems to boost levels of hypocretin(involved in appetite, arousal as well as alertness.) The eugregorics in the -afinil family may operate via glutamergic signalling. Glutamate is the brain’s primary excitatory receptor system. It is responsible for causing neurons to fire off as well as halting GABAergic inhibition.

Adrafanil (or the other modafinil analogues) should not be used for extended periods of time. Adrafnil is not recommended for those with existing liver conditions. Skin related issues like minor rash, some stomach upset and anxiety are the most common side effects. Due to it’s long half life it’s not suggested to take after noon. Adrafinil may have an effect on liver enzymes and as a result, could cause interaction with certain drugs affected by those cytochrome enzymes. Make sure to check for interactions if you’re currently on any prescription or other medication.




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