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Limitless Longevity Research Formula

$225.00

5-Amino 1MQ 50 mg,

JBSNF-000088 5 mg,

NMN 50 mg (60) 50 mg capsules

This product is packaged in a bottle with 60 capsules

 

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Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given its go-ahead for the treatment or prevention of any disease, medical condition, or ailment using them.

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Limitless Longevity Research Formula

5-amino-1MQ inhibits nicotinamide N-methyltransferase activity (NNMT). 5-amino-1MQ blocks NNMT to raise NAD+, a coenzyme important to cellular metabolism, raising metabolic rate and activating sirtuin-1 (SIRT1). SIRT1 is the “longevity gene” since in studies it reduces the risk of diabetes, obesity, metabolic syndrome, atherosclerosis, renal disease, liver disease, neurodegeneration, and cancer.

NMN (Nicotinamide mononucleotide) is a precursor to the cofactor NADH, which helps enzymes critical to metabolism and DNA repair function properly. Research has shown NMN to reduce age-associated body weight gain, improve energy metabolism, improve insulin sensitivity and plasma lipid profile, enhance eye function, and other pathophysiologies.

JBSNF-000088 decreases MNA levels, increases insulin sensitivity, and reduces body weight in animal models of metabolic illness. In mice with HFD-induced obesity, JBSNF-000088 reduced body weight, enhanced insulin sensitivity, and corrected glucose tolerance.

These three substances have an effect on everything from the metabolism of energy to the functioning of cells as well as the aging process. They do this largely via influencing the concentration of NAD, as well as the expression of GLUT-4 receptors, the activity of the NNMT enzyme, and the creation of chemicals known as sirtuins. Together, these molecules combine to increase cellular metabolism, which in turn helps with weight reduction and glucose management. This is accomplished by elevating cellular levels of NAD while simultaneously lowering the activity of NNMT. The synergy between these chemicals has other advantages, one of which is evident in the process of cellular aging, where it helps stem cells to survive and flourish when there are greater amounts of NAD. This results in an increased pool of healthy cells that can rapidly replace worn out or damaged cells, leading to greater tissue function and a reduction in the symptoms of aging. It is believed that by combining these three substances, it will be feasible to bring about significant improvements in energy metabolism while at the same time enhancing the anti-aging, anti-inflammatory, and anti-apoptosis action that is present in cells.

5-Amino 1MQ

5-Amino-1-methylquinolinium.png

CAS: 42464-96-0

Molecular Formula: C10H11N2+

 

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826726/

https://www.evolving-science.com/bioengineering/new-drug-may-be-ultimate-pharmaceutical-grail-people-obesity-00547

https://apps.dtic.mil/dtic/tr/fulltext/u2/1059191.pdf

https://superhumanradio.net/shr-2434-the-pep-talk-can-this-small-molecule-reverse-the-obesogenic-effects-of-the-standard-american-diet

 

NMN

Nicotinamide mononucleotide.svg

CAS: 1094-61-7

Chemical Formula: C11H15N2O8P

 

References:

  1.  Bogan KL, Brenner C (2008). “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition”. Annual Review of Nutrition28: 115–30. doi:10.1146/annurev.nutr.28.061807.155443PMID 18429699.
  2. ^ Grozio, A; Mills, KF; Yoshino, J; Bruzzone, S; Sociali, G; Tokizane, K; Lei, HC; Cunningham, R; Sasaki, Y; Migaud, ME; Imai, SI (January 2019). “Slc12a8 is a nicotinamide mononucleotide transporter”Nature Metabolism1 (1): 47–57. doi:10.1038/s42255-018-0009-4PMC 6530925PMID 31131364.
  3. ^ Schmidt, MS; Brenner, C (July 2019). “Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter”. Nature Metabolism1 (7): 660–661. doi:10.1038/s42255-019-0085-0PMID 32694648S2CID 203899191.
  4. ^ Chini, CCS; Zeidler, JD; Kashyap, S; Warner, G; Chini, EN (1 June 2021). “Evolving concepts in NAD+ metabolism”Cell Metabolism33 (6): 1076–1087. doi:10.1016/j.cmet.2021.04.003PMC 8172449PMID 33930322.
  5. ^ Brazill JM, Li C, Zhu Y, Zhai RG (June 2017). “+ synthase… It’s a chaperone… It’s a neuroprotector”Current Opinion in Genetics & Development44: 156–162. doi:10.1016/j.gde.2017.03.014PMC 5515290PMID 28445802.
  6. ^ Mills, Kathryn F.; Yoshida, Shohei; Stein, Liana R.; Grozio, Alessia; Kubota, Shunsuke; Sasaki, Yo; Redpath, Philip; Migaud, Marie E.; Apte, Rajendra S.; Uchida, Koji; Yoshino, Jun; Imai, Shin-Ichiro (13 December 2016). “Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice”Cell Metabolism24 (6): 795–806. doi:10.1016/j.cmet.2016.09.013PMC 5668137PMID 28068222.
  7. ^ Stipp D (March 11, 2015). “Beyond Resveratrol: The Anti-Aging NAD Fad”Scientific American Blog Network.
  8. ^ Irie, Junichiro; Inagaki, Emi; Fujita, Masataka; Nakaya, Hideaki; Mitsuishi, Masanori; Yamaguchi, Shintaro; Yamashita, Kazuya; Shigaki, Shuhei; Ono, Takashi; Yukioka, Hideo; Okano, Hideyuki (2020). “Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men”Endocrine Journal67 (2): 153–160. doi:10.1507/endocrj.EJ19-0313ISSN 0918-8959PMID 31685720.
  9. ^ Yoshino, M; Yoshino, J; Kayser, BD; Patti, GJ; Franczyk, MP; Mills, KF; Sindelar, M; Pietka, T; Patterson, BW; Imai, SI; Klein, S (11 June 2021). “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women”Science372 (6547): 1224–1229. Bibcode:2021Sci…372.1224Ydoi:10.1126/science.abe9985PMC 8550608PMID 33888596.
  10. ^ “”Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study””.
  11. Jump up to:a b Fletcher RS, Lavery GG (October 2018). “The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism”Journal of Molecular Endocrinology61 (3): R107–R121. doi:10.1530/JME-18-0085PMC 6145238PMID 30307159.
  12. Jump up to:a b Cambronne XA, Kraus WL (October 2020). “+ Synthesis and Functions in Mammalian Cells”Trends in Biochemical Sciences45 (10): 858–873. doi:10.1016/j.tibs.2020.05.010PMC 7502477PMID 32595066.
  13. Jump up to:a b “NMN vs NR: The Differences Between These 2 NAD+ Precursors”www.nmn.com. Retrieved 2021-01-11.
  14. ^ Tarragó, MG; Chini, CCS; Kanamori, KS; Warner, GM; Caride, A; de Oliveira, GC; Rud, M; Samani, A; Hein, KZ; Huang, R; Jurk, D; Cho, DS; Boslett, JJ; Miller, JD; Zweier, JL; Passos, JF; Doles, JD; Becherer, DJ; Chini, EN (1 May 2018). “A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline”Cell Metabolism27 (5): 1081–1095.e10. doi:10.1016/j.cmet.2018.03.016PMC 5935140PMID 29719225.
  15. ^ Ryan, Finn (2016-12-06). “5 Anti-Aging Food Types You Should Already Be Eating”Bicycling. Retrieved 2022-01-20.
  16. ^ “Scientists identify new fuel-delivery route for cells”Washington University School of Medicine in St. Louis. 2019-01-07. Retrieved 2022-01-20.

 

JBSNF-000088

6-Methoxynicotinamide.png

Molecular Formula: C7H8N2O2

CAS: 7150-23-4

 

Source:

https://pubchem.ncbi.nlm.nih.gov/compound/250810#section=InChI

https://www.sciencedirect.com/science/article/pii/S2212877821000053

https://www.researchgate.net/publication/323399959_A_small_molecule_inhibitor_of_Nicotinamide_N-methyltransferase_for_the_treatment_of_metabolic_disorders

https://digital.csic.es/bitstream/10261/259149/1/nicotinaregula.pdf

 

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3 Grams, 6 Grams, 9 Grams

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