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Semax (30mg)


Glass Vial

Add'l Information


Reference Standard 99%+


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Most orders are processed out the same day they are placed.

3rd Party Tested

Our testing lab confirms peptides sequential signatures


Semax Fact Sheet

Molecular formula: C37H51N9O10S
Molecular weight:
813.9 g/mol
Purity: 99%+
  • Semax
  • 80714-61-0
  • ACTH (4-7), Pro-Gly-Pro-
  • Met-Glu-His-Phe-Pro-Gly-Pro
Research Applications:
  • Attention and short-term memory
  • Improving non-proliferative diabetic neuropathy
  • Assistance in recovery from stroke/hypoxia
  • Reducing anxiety and depression
  • Improving mental clarity and focus

Semax Peptide Research

Semax is a synthetic peptide drug originally developed in Russia to prevent and treat circulatory disorders, such as strokes and brain damage. It has neuroprotective, nootropic, and neurorestorative properties, which can benefit cognitive function and overall brain health.

Semax works by stimulating parts of the brain involved in the release of brain-derived neurotrophic factor (BDNF), which plays a role in neurogenesis and the survival of existing neurons. It also helps prevent the breakdown of enkephalins, which are important for pain relief, reducing inflammation, immunity, memory, learning, and emotional behavior.

Semax and Attention and Short-Term Memory

Semax has been found to rapidly elevate the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus, a region of the brain associated with learning and memory. BDNF is a protein that supports the survival of existing neurons, encourages the formation of new neurons and synapses, and is vital for long-term memory.

A 1996 study found that Semax improved attention and short-term memory in 11 healthy subjects performing 8-hour work shifts. Another study done in Russia found that Semax improved memory retention and attention in men in good health [R, R].

Research has also shown that Semax can have a protective effect on episodic memory function. In a study involving Sprague-Dawley rats exposed to hypoxic conditions, Semax treatment was found to prevent impairments in the novel object recognition (NOR) test, which is a measure of episodic memory performance [R].

Semax and Non-Proliferative Diabetic Neuropathy

Research has shown that Semax can be beneficial in the treatment of non-proliferative diabetic neuropathy. A study involving 114 patients with non-proliferative diabetic retinopathy showed positive dynamics in visual, perimetric, and electrophysiological characteristics in patients treated with Semax. The most pronounced and long-standing positive effect on visual function was documented in the group that underwent endonasal electrophoresis of 0.1% Semax preparation [R].

Semax and Recovery from Stroke/Hypoxia

Research has shown that Semax can stimulate operative memory and attention, increase resistance to hypoxia, and improve brain circulation in experimental animals and humans. It has been found to have a positive influence on the rate of restoration of damaged neurological functions, particularly in terms of reducing general cerebral and focal, especially motor disorders, in patients with acute ischemic stroke. In animal studies, Semax has been found to protect memory function in rats exposed to hypoxia, hyperoxia, and oscillatory hypoxia-hyperoxia [R, R, R]. 

Semax and Cognitive Performance, Mental Clarity and Focus

Semax has also been studied for its potential applications in treating memory impairment, decreased efficiency of mental labor, and symptoms associated with post-COVID syndrome. The peptide is believed to enhance the transcription of neurotrophins and their receptors, modulate the expression of genes involved in the immune response, and suppress the expression of inflammatory genes [R].

In a study involving a rat model of cerebral ischemia, Semax was found to suppress inflammatory and cell death processes and activate recovery processes. This was evidenced by the upregulation of active CREB (a protein involved in neuroprotection and recovery) in subcortical structures, including the focus of ischemic damage, and the downregulation of MMP-9, c-Fos, and active JNK (proteins involved in inflammation and cell death) in the adjacent frontoparietal cortex [R].

Semax and Epilepsy

In a study involving rats with epilepsy, Semax was found to reduce malondialdehyde (MDA) levels by up to 40.46% and synthesize three kinds of proteins that were not synthesized in epilepsy rats. These proteins had molecular weights of 93.54 kDa, 66.76 kDa, and 59.66 kDa. This suggests that Semax could potentially be used for the treatment of epilepsy [R].

Semax May Reduce Anxiety and Depression

In a study on rats, Semax was found to increase the proliferation of neuroglia, blood vessel endothelium, and progenitor cells in the subventricular zone. This suggests that Semax may have a trophic effect on the brain, promoting the growth and development of cells.  In the same study, Semax was also found to reduce the manifestation of ischemic damage to the nervous tissue, possibly due to a decrease in vascular stasis symptoms [R].

Another study found that Semax had a more pronounced immunomodulatory effect compared to Cortexin, another peptide preparation, and both showed a stress-protective effect. This suggests that Semax could potentially help to mitigate the physiological responses to stress, which could in turn have a positive impact on mental health conditions like anxiety and depression [R].


What is Semax Spray?

Semax spray is a synthetic peptide derived from adrenocorticotropic hormone (ACTH) and is known for its nootropic, neuroprotective, and neurorestorative properties. It is primarily researched for its ability to enhance cognitive function, protect brain cells, and alleviate depression and anxiety. In studies, Semax is typically administered as a nasal spray.

How Does Semax Work?

Semax works by stimulating parts of the brain, including the hippocampus, the limbic reticular complex, and several receptors. It increases the levels of brain-derived neurotrophic factor (BDNF), which is responsible for the growth, maintenance, and survival of neurons. Semax also helps mitigate the breakdown of enkephalins, which are important for pain relief, reducing inflammation, immunity, memory, learning, and emotional behavior.

What are the Researched Benefits of Semax Spray?

Some of the main researched benefits of Semax spray include:

  • Cognitive enhancement: Semax improves focus, concentration, memory performance, and reduces the negative effects of stress
  • Neuroprotective properties: Semax supports overall brain health and protects neurons from damage
  • Mood enhancement: Semax may help alleviate depression and anxiety by increasing BDNF levels
  • Potential therapeutic applications: Semax has been used in the treatment of stroke, traumatic brain injury, and ADHD

Has Semax been researched for the treatment of ADHD?

There is evidence suggesting that Semax may be a potential agent for the treatment of attention-deficit hyperactivity disorder (ADHD). However, more research is needed to confirm its effectiveness for this condition.

What is the difference between Semax and Selank?

Semax and Selank are both synthetic peptides with nootropic and neuroprotective properties. While Semax is primarily known for its cognitive enhancement and neuroprotective effects, Selank research is more focused on reducing anxiety and stress, as well as improving mood and emotional stability.

Where to Buy Semax Nasal Spray?

Semax nasal spray can be purchased online from reputable biotech suppliers such as Limitless Life Nootropics. Limitless offers a wide selection of USA peptides for sale online for scientific research and development purposes.

Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.


Semax 30mg

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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