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Retatrutide HA 12mg (2x 6mg Vials)

$319.99

Container

Glass Vial

Presentation

Solid Crystals

In Stock

Every 12mg order will receive 2, 6-mg bottles.

 

Fast Shipping

Most orders are processed out the same day they are placed.

3rd Party Tested

Our testing lab confirms peptides sequential signatures

Lyophilized Peptides: These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage.

Non-Lyophilized Peptides: Offered as a dry powder, these peptides, while not as extensively processed as lyophilized peptides, still maintain a high level of purity. Their stability, though not as enhanced as in lyophilized form, is sufficient for maintaining quality under proper storage conditions.

98.5% vs. 99% Purity: Both grades are manufactured in our US-based facility and tested for quality at a third party lab. While the 99%+ purity grade is our highest reference grade product line, the 98.5% purity variants still exceed US pharmaceutical standards.

Research

Retatrutide Peptide Structure

Molecular formula: C223H343F3N46O70
Molecular weight: 4845.44ย g/mol
PubChem SID:
  • 474492335
Synonyms
  • LY3437943
Research Applications:
  • Weight Loss and Obesity
  • Type 2 Diabetes
  • Fatty Liver Disease

Retatrutide Overview

Retatrutide is a novel triple receptor agonist peptide developed by Eli Lilly that simultaneously targets the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).ย The peptide’s mechanism of action involves reducing food intake, increasing energy expenditure, and potentially stimulating hepatic fatty acid oxidation while reducing hepatic lipogenesis.

Retatrutide in Weight Loss and Obesity

Retatrutide has shown promising results in clinical trials for weight loss and obesity treatment. In a phase 2 trial involving adults with obesity or overweight, retatrutide demonstrated substantial weight reduction over 48 weeks. Participants receiving the highest dose of retatrutide experienced a mean weight loss of 24.2% of their body weight, equivalent to about 58 pounds [R].

The study also found that retatrutide’s effects on weight loss had not plateaued by the end of the 48-week period, suggesting potential for even greater weight reduction with longer treatment duration. Additionally, all participants in the highest-dose group achieved at least 5% weight loss, with 26% of participants losing 30% or more of their baseline weight [R].

Beyond weight loss, retatrutide showed improvements in various cardiometabolic measures. Participants experienced reductions in waist circumference, blood pressure, triglycerides, and cholesterol levels. Retatrutide also demonstrated positive effects on insulin sensitivity and glycemic control, with nearly three-quarters of prediabetic participants returning to normal blood sugar levels after 48 weeks of treatment [R].

In a substudy focusing on participants with fatty liver disease, retatrutide showed remarkable efficacy in reducing liver fat content. Over 85% of participants taking the higher doses of retatrutide reduced their liver fat to levels below the threshold for fatty liver disease classification. This suggests potential applications for retatrutide in preventing or reversing liver disease associated with obesity [R].

Ongoing phase 3 trials are expected to provide more comprehensive data on retatrutide’s potential as a therapeutic option for obesity and its related complications.

Retatrutide in Type 2 Diabetes

Recent clinical research on retatrutide, a novel triple-hormone receptor agonist, has shown promising results for people with type 2 diabetes. In a phase 2 clinical trial, retatrutide demonstrated significant improvements in glycemic control and substantial weight loss in participants with type 2 diabetes over a 36-week period. The study found that participants taking retatrutide lowered their HbA1c by 1.3% to 2.0%, compared to no change with placebo. Notably, up to 82% of participants achieved an A1C level below 6.5%, and up to 31% reached an A1C level below 5.7%, indicating a potential for normalization of blood glucose levels in some patients [R].

In addition to glycemic improvements, retatrutide showed remarkable effects on body weight. Participants with type 2 diabetes experienced an average weight reduction of 16.9% over the 8-month study period, which is considered the most substantial weight loss reported so far for a medication tested in type 2 diabetes treatment [R].

Clinical trials also revealed that retatrutide treatment led to a reversion to normoglycemia in 72% of participants who had prediabetes at baseline. This finding suggests potential benefits for diabetes prevention or early intervention. Furthermore, retatrutide demonstrated improvements in insulin sensitivity and reductions in low-density lipoprotein cholesterol levels by approximately 20% [R].

These findings support the continued development of retatrutide as a potential treatment option for type 2 diabetes, with ongoing phase 3 trials set to further evaluate its efficacy and safety.

FAQ

Is Retatrutide a GLP-1 Receptor Agonist?

Retatrutide is not simply a GLP-1 receptor agonist, but a triple hormone receptor agonist. It activates three different receptors:

  • GLP-1 (glucagon-like peptide-1) receptor
  • GIP (glucose-dependent insulinotropic polypeptide) receptor
  • GCG (glucagon) receptor

This unique mechanism of action is why retatrutide is sometimes referred to as a “triple G” agonist. Specifically, retatrutide (LY3437943) is a single peptide molecule designed to activate all three of these hormone receptors.

Where to Buy Retatrutide Online for Research Use

Researchers can buy retatrutide online from reputable biotech suppliers such as Limitless Biotech. We offer a wide selection of USA peptides for sale onlineย for scientific research and development purposes.

Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.

Are There Other Peptide Candidates for Diabetes and Obesity Research?

A number of other peptides have been investigated for their potential anti-obesity and anti-diabetic properties. Please visit the following pages for more information:

COA

Report 99% + grade

COA_Retatrutide_6mg_1202-79 vial2_2024-10-08 COA_Retatrutide_6mg_1202-79 vial2_2024-10-08 COA_Retatrutide_6mg_1202-79 vial2_2024-10-08 COA_Retatrutide_6mg_1202-79 vial2_2024-10-08

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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