Research
P21 Peptide Structure
| Molecular formula: | C30H54N6O5 |
| Molecular weight: |
578.8Â g/mol
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| Synonyms |
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| Research Applications: |
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What is P21?
P21 peptide is a synthetic analog of ciliary neurotrophic factor (CNTF), designed to mimic its neurotrophic effects. Engineered through epitope mapping, P21 is composed of specific amino acid sequences that enhance its stability and ability to cross the blood-brain barrier. Unlike CNTF, which directly binds to its receptor, P21 functions by inhibiting molecules that neutralize CNTF, thereby promoting neurogenesis and cognitive functions.
P21 and Neurogenesis
The P21 peptide has shown promise in research focused on neurogenesis and cognitive function. Studies indicate that P21 can promote the growth and maturation of new neurons in the hippocampus, a brain region critical for memory and learning. The nootropic peptide appears to enhance neurogenesis by stimulating the proliferation of neural progenitor cells and supporting their development into mature neurons [R, R].
P21 and Appetite Regulation
Emerging research suggests that the p21 peptide may also have potential applications in appetite regulation. Although direct studies on p21’s impact on food intake are limited, there is a rationale to believe that it could act as an appetite suppressant. This hypothesis is based on p21’s ability to stimulate the synthesis of alpha-melanocyte-stimulating hormone (alpha-MSH), which is known to reduce food intake [R].
