NMN 99%

NMN

Molecular Formula: C11H15N208P

CAS: 1094-61-7

NMN (Nicotinamide mononucleotide) is a precursor to the cofactor NADH, which helps enzymes critical to metabolism and DNA repair function properly. Research has shown NMN to reduce age-associated body weight gain, improve energy metabolism, improve insulin sensitivity and plasma lipid profile, enhance eye function, and other pathophysiologies.

References:

1.  Bogan KL, Brenner C (2008). “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition”. Annual Review of Nutrition. 28: 115–30. doi:10.1146/annurev.nutr.28.061807.155443. PMID 18429699.
2. ^ Grozio, A; Mills, KF; Yoshino, J; Bruzzone, S; Sociali, G; Tokizane, K; Lei, HC; Cunningham, R; Sasaki, Y; Migaud, ME; Imai, SI (January 2019). “Slc12a8 is a nicotinamide mononucleotide transporter”. Nature Metabolism. 1 (1): 47–57. doi:10.1038/s42255-018-0009-4. PMC 6530925. PMID 31131364.
3. ^ Schmidt, MS; Brenner, C (July 2019). “Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter”. Nature Metabolism. 1 (7): 660–661. doi:10.1038/s42255-019-0085-0. PMID 32694648. S2CID 203899191.
4. ^ Chini, CCS; Zeidler, JD; Kashyap, S; Warner, G; Chini, EN (1 June 2021). “Evolving concepts in NAD⁺ metabolism”. Cell Metabolism. 33 (6): 1076–1087. doi:10.1016/j.cmet.2021.04.003. PMC 8172449. PMID 33930322.
5. ^ Brazill JM, Li C, Zhu Y, Zhai RG (June 2017). “+ synthase… It’s a chaperone… It’s a neuroprotector”. Current Opinion in Genetics & Development. 44: 156–162. doi:10.1016/j.gde.2017.03.014. PMC 5515290. PMID 28445802.
6. ^ Mills, Kathryn F.; Yoshida, Shohei; Stein, Liana R.; Grozio, Alessia; Kubota, Shunsuke; Sasaki, Yo; Redpath, Philip; Migaud, Marie E.; Apte, Rajendra S.; Uchida, Koji; Yoshino, Jun; Imai, Shin-Ichiro (13 December 2016). “Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice”. Cell Metabolism. 24 (6): 795–806. doi:10.1016/j.cmet.2016.09.013. PMC 5668137. PMID 28068222.
7. ^ Stipp D (March 11, 2015). “Beyond Resveratrol: The Anti-Aging NAD Fad”. Scientific American Blog Network.
8. ^ Irie, Junichiro; Inagaki, Emi; Fujita, Masataka; Nakaya, Hideaki; Mitsuishi, Masanori; Yamaguchi, Shintaro; Yamashita, Kazuya; Shigaki, Shuhei; Ono, Takashi; Yukioka, Hideo; Okano, Hideyuki (2020). “Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men”. Endocrine Journal. 67 (2): 153–160. doi:10.1507/endocrj.EJ19-0313. ISSN 0918-8959. PMID 31685720.
9. ^ Yoshino, M; Yoshino, J; Kayser, BD; Patti, GJ; Franczyk, MP; Mills, KF; Sindelar, M; Pietka, T; Patterson, BW; Imai, SI; Klein, S (11 June 2021). “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women”. Science. 372 (6547): 1224–1229. Bibcode:2021Sci…372.1224Y. doi:10.1126/science.abe9985. PMC 8550608. PMID 33888596.
10. ^ “”Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study””.
11. ^ Jump up to:^a b Fletcher RS, Lavery GG (October 2018). “The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism”. Journal of Molecular Endocrinology. 61 (3): R107–R121. doi:10.1530/JME-18-0085. PMC 6145238. PMID 30307159.
12. ^ Jump up to:^a b Cambronne XA, Kraus WL (October 2020). “+ Synthesis and Functions in Mammalian Cells”. Trends in Biochemical Sciences. 45 (10): 858–873. doi:10.1016/j.tibs.2020.05.010. PMC 7502477. PMID 32595066.
13. ^ Jump up to:^a b “NMN vs NR: The Differences Between These 2 NAD+ Precursors”. www.nmn.com. Retrieved 2021-01-11.
14. ^ Tarragó, MG; Chini, CCS; Kanamori, KS; Warner, GM; Caride, A; de Oliveira, GC; Rud, M; Samani, A; Hein, KZ; Huang, R; Jurk, D; Cho, DS; Boslett, JJ; Miller, JD; Zweier, JL; Passos, JF; Doles, JD; Becherer, DJ; Chini, EN (1 May 2018). “A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD⁺ Decline”. Cell Metabolism. 27 (5): 1081–1095.e10. doi:10.1016/j.cmet.2018.03.016. PMC 5935140. PMID 29719225.
15. ^ Ryan, Finn (2016-12-06). “5 Anti-Aging Food Types You Should Already Be Eating”. Bicycling. Retrieved 2022-01-20.
16. ^ “Scientists identify new fuel-delivery route for cells”. Washington University School of Medicine in St. Louis. 2019-01-07. Retrieved 2022-01-20.