Research
N-acetyl Semax Research
N-acetyl Semax is a synthetic heptapeptide developed by Russian researchers. It is derived from a fragment of adrenocorticotropic hormone (ACTH), specifically ACTH (4-10). N-acetyl Semax has gained attention for its nootropic properties. In Russia, N-acetyl Semax amidate is used to treat acute cerebral hypoxia, such as in cases of stroke or traumatic brain injury.
Studies have demonstrated that Semax promotes neuron survival during hypoxia and protects against glutamate neurotoxicity. Research conducted on rats has shown that N-acetyl Semax stimulates various molecular mechanisms involved in gene transcription within the central nervous system (CNS). Specifically, it induces changes in the expression of 24 different genes related to blood vessel function in the brain and spinal cord.
N-acetyl Semax Structure
PubChem CID: 122178
Molecular Formula: C37H51N9O10S
Molecular Weight: 159.21
Synonyms: DTXSID601001439, Q4415058, L-Methionyl-L-alpha-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L-proline
Source: PubChem
Semax and Treatment of Ischemic Strokes
Semax has been used in the treatment of neurological disorders like ischemic stroke and has shown promising results in various studies. Key findings from the research include:
- Enhanced brain circulation: Semax has demonstrated the ability to improve circulation in the brain, a crucial factor in stroke risk. Patients with cerebrovascular insufficiency experienced disease stabilization and reduced stroke risk when treated with Semax.
- Neuroprotective effects: Studies conducted on rats have indicated that Semax has neuroprotective properties, shielding the heart from damage following a stroke or heart attack. Additionally, patients recovering from ischemic stroke showed improved nerve function restoration with Semax compared to those without the treatment.
- Memory improvement: Some researchers have theorized that Semax may enhance memory by increasing the brain’s resistance to oxidative damage and improving circulation.
- BDNF levels: Semax has been found to elevate BDNF plasma levels, which can lead to improved motor performance and faster functional recovery in patients after an ischemic stroke.
Semax and Cognition
Semax has been found to have cognitive effects in animal studies that go beyond protecting and recovering from acute brain injury. Here are some key findings:
Semax affects cognitive brain functions by regulating the expression and activation of the hippocampal BDNF/trkB system. It works through chemical stimulation on the limbic reticular complex, hippocampus, and the body’s systems and receptors.
In animal studies, Semax has demonstrated improvements in working memory, focus, and learning. It has been used for conditions such as anti-thrombosis, ADHD, learning difficulties, gastric protection, physical exertion, pain relief, and metal toxicity. Semax has also been reported to significantly enhance memory and attention in healthy men during extreme activities.
References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987924/
https://pubmed.ncbi.nlm.nih.gov/11517472/
https://pubmed.ncbi.nlm.nih.gov/29798983/
https://www.mdpi.com/2073-4425/14/5/953/
https://pubmed.ncbi.nlm.nih.gov/16996037/
