Research
Selank Spray Peptide Information
| Molecular formula: | C33H57N11O9 |
| Molecular weight: | 751.9Â g/mol |
| PubChem CID: | 11765600 |
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| Research Applications: |
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What is Selank?
Selank is a synthetic peptide developed by Russian researchers as an analog of the naturally occurring tuftsin molecule. This heptapeptide has been studied for its potential anxiolytic and nootropic effects in animal models. Research suggests Selank may influence neurotransmitter systems, particularly GABA, serotonin and dopamine pathways. Some studies indicate it could affect memory formation, stress responses, and cognitive function.
Anxiolytic Effects
Selank peptide has been extensively studied for its anxiolytic properties, demonstrating significant potential in reducing anxiety levels. Clinical trials have shown that Selank can effectively alleviate symptoms of generalized anxiety disorder (GAD) and neurasthenia, with efficacy comparable to benzodiazepine treatments. Selank has also been found to inhibit enkephalin-degrading enzymes, which may contribute to its anxiolytic activity [R, R].
Memory and Learning Processes
Research has highlighted Selank’s ability to improve cognitive function, particularly in memory consolidation and learning processes. Studies indicate that Selank improves memory storage processes and increases the stability of memory traces for an extended period. This suggests that the peptide may have long-lasting effects on memory consolidation and retention [R].
Additionally, Selank has shown promise in restoring cognitive processes that have been impaired due to damage to the cerebral catecholamine system [R].
Immunomodulatory Effects
Selank demonstrated notable immunomodulatory effects in patients with anxiety-asthenic disorders. The research revealed that Selank had a significant impact on interleukin-6 (IL-6), a key cytokine involved in immune responses.
Research found that Selank altered the balance between T helper 1 (Th1) and T helper 2 (Th2) cytokines in vivo. This shift in the Th1/Th2 cytokine ratio suggests that Selank may influence the overall immune response by modulating the activity of different T helper cell subsets [R].
Neuroprotection
Selank administration led to significant changes in the mRNA levels of 45 genes related to neurotransmission, similar to the effects observed with GABA administration. This suggests that Selank may act through allosteric modulation of GABA receptors, altering their affinity for GABA and affecting neurotransmission. Selank’s impact on gene expression was not limited to the GABAergic system; it also affected genes related to dopamine and serotonin systems, indicating a broader neuroprotective role [R].
