Research
Ibutamoren (MK677) Fact Sheet
Molecular formula: |
C27H36N4O5S |
Molecular weight: |
528.7 g/mol |
Purity: |
99%+ |
Synonyms |
- Ibutamoren
- 159634-47-6
- Ibutamoren [INN]
- UNII-GJ0EGN38UL
- GJ0EGN38UL
|
Research Applications: |
- Muscle Growth and Fat Loss
- Bone Health
- Improved Sleep
- Cognitive Benefits
- Skin Health
|
MK-677 Research Overview
MK-677 is an orally active growth hormone secretagogue that has been found to significantly increase growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in healthy older adults without serious adverse effects. It has been associated with increased fat-free mass (FFM), body cell mass, and body weight, while not significantly affecting abdominal visceral fat or total fat mass. Â MK-677 also showed potential in increasing markers of bone formation and resorption, suggesting it could have implications for bone health.
MK-677 (Ibutamoren) and Growth Hormone
MK-677, also known as Ibutamoren, is an orally active growth hormone secretagogue that stimulates the release of growth hormone (GH) in the body. It has been shown to increase GH and insulin-like growth factor 1 (IGF-1) levels in both young and older adults [R, R].
In a study with healthy elderly subjects, daily oral administration of MK-677 for two weeks increased GH concentrations in a dose-dependent manner, with a 25 mg/day dose increasing the mean 24-hour GH concentration by 97%. However, the long-term effects of MK-677 on somatic growth in rats were not observed, despite the GH stimulatory effect of MK-677 [R].
MK-677 and Bone Health
MK-677 has been shown to have a positive impact on bone health. In a study with healthy postmenopausal women, daily oral administration of MK-677 for six weeks increased bone mineral content and bone mineral density at the lumbar spine and femoral neck. Another study found that MK-677 administration in rats increased the width of the tibia growth plate, although it did not increase body growth or serum levels of IGF-I [R, R].
MK-677 and Sleep Quality
MK-677 has been shown to improve sleep quality in both young and older adults. In a study with healthy young subjects, high-dose MK-677 treatment resulted in an approximately 50% increase in the duration of stage IV sleep and a more than 20% increase in REM sleep compared to placebo. n older adults, treatment with MK-677 was associated with a nearly 50% increase in REM sleep and a decrease in REM latency [R].
These findings suggest that MK-677 may improve sleep quality and potentially correct the relative hyposomatotropism of senescence.
MK-677 and Skin Health
There is limited research on the direct effects of MK-677 on skin health. However, since MK-677 increases GH and IGF-1 levels, it may indirectly contribute to skin health. GH and IGF-1 play essential roles in skin homeostasis, wound healing, and collagen synthesis.
FAQ
What is MK-677 (Ibutamoren)?
MK-677, also known as Ibutamoren, is a growth hormone secretagogue that promotes the secretion of growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1). It is an orally active, selective, and non-peptide agonist of the ghrelin receptor.
What are the potential research benefits of MK 677?
MK-677 has been researched for its potential benefits in various contexts. The primary benefits of MK-677 include:
- Increased muscle mass
- Reduced muscle wasting
- Improved bone density
- Enhanced sleep quality
- Reversing diet-induced catabolism
It is important to note that MK-677 is strictly sold for research purposes only.
How does MK-677 work?
MK-677 is a growth hormone secretagogue that promotes the secretion of growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1). It works by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. This binding stimulates the release of GH.
Can I buy MK-677 for research purposes?
MK-677 can be purchased for laboratory research use only.
Has MK-677 been shown to impact body composition?
MK-677 has been shown in various studies to have an impact on body composition. It has been found to increase body mass, fat mass, muscle mass, bone mineral density, and total body water, while also improving physical function [R].
Has MK-677 been used for growth hormone deficiency?
Research has shown that MK-677 can stimulate the GH/IGF-I axis in selected GH-deficient adults, suggesting its potential use in treating GH deficiency. In a study involving GH-deficient adults, MK-677 treatment was found to increase circulating GH and IGF-I levels [R].
Can MK-677 increase GH and IGF-1 levels?
Research studies have shown that MK-677 can increase GH and IGF-1 levels. For instance, in a randomized, controlled trial, healthy elderly individuals who took MK-677 experienced a sustained increase in GH and IGF-1 levels. The likely mechanism was activation of the ghrelin receptor by MK-677, with feedback by IGF-1 preventing excess GH production [R].
Has MK-677 been studied for Alzheimer’s disease?
In a large-scale clinical trial involving 416 people with mild to moderate Alzheimer’s disease, half of the participants were given MK-677 and the other half a placebo for one year. The study found that MK-677 did not slow the symptoms of Alzheimer’s disease, even though it successfully boosted the blood levels of insulin-like growth factor 1 (IGF-1), a hormone that some studies on mice suggested could help reduce beta-amyloid, a form of plaque, from the brain [R].
Has MK-677 been studied for increasing testosterone levels?
Some studies suggest that MK-677 does not directly affect testosterone levels. However, one study found that MK-677 treatment reduced serum total testosterone, although it remained within the normal range. Therefore, while MK-677 can increase growth hormone levels, its effect on testosterone levels may vary and further research is needed to clarify this relationship [R].
Has MK-677 been studied for cholesterol levels?
MK-677 has been shown to decrease low-density lipoprotein cholesterol levels. However, there were no differences in total or high-density lipoprotein cholesterol.
Has MK-677 been studied for improving nitrogen retention?
MK-677 has been studied for its potential to improve nitrogen retention, particularly in the context of reversing diet-induced catabolism. A study published in the Journal of Clinical Endocrinology & Metabolism reported that MK-677 significantly improved nitrogen balance when administered to subjects under caloric restriction [R].
Has MK-677 been studied for sleep duration and quality?
Research has shown that prolonged oral treatment with MK-677 can improve sleep quality in both young and older adults. In young subjects, high-dose MK-677 treatment resulted in an approximately 50% increase in the duration of stage IV sleep and a more than 20% increase in REM sleep. Additionally, the frequency of deviations from normal sleep patterns decreased significantly when subjects were treated with MK-677 compared to a placebo [R].
Has MK-677 been studied for lean body mass?
A study found that MK-677 treatment led to an increase in fat-free mass (FFM), suggesting an improvement in body composition. Another study observed that oral administration of MK-677 reversed protein catabolism caused by dietary caloric restriction, indicating its potential utility as an adjunctive therapy in catabolic states [R, R].
Has MK-677 been studied for bone density?
In a study involving obese young males, short-term treatment with MK-677 increased markers of both bone resorption and formation. Another study found that MK-677 treatment rapidly increased biochemical markers of bone resorption [R, R].
Is MK-677 available for sale online?
MK-677 can be purchased online from reputable biotech suppliers such as Limitless Biotech. Limitless Life offers a wide selection of USA peptides for sale online for scientific research and development purposes.
Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.