Research
Mazdutide Peptide Structure
| Molecular formula: | C207H317N45O65 |
| Molecular weight: | 4476ย g/mol |
| PubChem CID: | 167312357 |
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Mazdutide Research Overview
Mazdutideย isย a synthetic peptide thatย acts as a dualย agonist of theย glucagon-like peptide-1 (GLP-1) receptor andย the glucagon receptorย (GCGR). This dualย agonism allows Mazdutide to simultaneously reduceย weight, blood sugarย levels, and otherย comorbidities associated withย obesity and typeย 2 diabetes (T2D). Mazdutide isย structurallyย related to oxyntomodulin (OXM), a naturally occurringย peptide hormone.
Mazdutide binds potently to GLP-1 receptors and glucagon receptors in vitro. This is believed to contribute to its effects on glucose control and energy expenditure. In preclinical studies, mazdutide demonstrated the ability to decrease body weight and improve metabolic parameters in mice, including those with specific receptor knockouts (e.g., Gcgrย KO andย Glp1rย KO) [R].
Clinical trials have also demonstrated the efficacy of Mazdutide in both weight loss and glucose control.
In the DREAMS-2 study, Mazdutide showed superiority over dulaglutide in glycemic control and weight loss in patients with T2D. Mazdutide also showed improvements in multiple cardiometabolic risk factors, including blood pressure, lipids, serum uric acid, and liver enzymes, mostly greater than dulaglutide [R].
In the GLORY-1 study, Mazdutide demonstrated robust weight loss efficacy in adults with overweight or obesity, with significant reductions in body weight and improvements in liver fat content [R].
