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LL-37 Antimicrobial Peptide (5mg) – 98.5% Version

$74.50

Container

Glass Vial

Presentation

Fine Powder

In Stock

Frequently Bought Together

Sterile Vial (10 mL)

Reconstitution Solution (10ml)

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Our testing lab confirms peptides sequential signatures

Research

LL-37 Peptide Fact Sheet

Molecular formula: C205H340N60O53
Molecular weight: 4493 g/mol
Purity: 99%
Synonyms
  • Cathelicidin
  • 154947-66-7
  • ropocamptide
  • LL-37
  • Bac4
Research Applications:
  • Antimicrobial
  • Anti-biofilm properties
  • Wound Healing
  • Immunomodulation
  • Boosting immune function
  • Anti-inflammatory activity
  • Cancer prevention and bone repair
  • Cardioprotective effects
  • Lung health

LL-37 Antimicrobial Peptide Research

LL-37 is a peptide found in humans that has antimicrobial properties. It belongs to the cathelicidin family, which is known for its antimicrobial peptides with a conserved cathelin domain. LL-37 has been extensively studied for its abilities as an antimicrobial agent, as well as its potential as an anti-biofilm and immunomodulatory agent. It has also been researched for its potential applications in tissue repair, wound healing, and as a potential treatment for cancer.

LL-37 and Broad-Spectrum Antimicrobial Activity

LL-37 has been shown to have antimicrobial properties against bacteria, enveloped viruses, and fungi. It can kill bacteria through direct antibacterial activities and immunomodulation. LL-37 has broad-spectrum antimicrobial activity against both Gram-negative and Gram-positive bacteria, including drug-resistant strains [R, R].

LL-37 and Anti-Biofilm Properties

LL-37 has been considered as a potential alternative to conventional antibiotics due to its broad-spectrum antibacterial and anti-biofilm activities, as well as immunomodulatory functions. LL-37 has shown inhibitory effects against Staphylococcus aureus strains, which are often responsible for wound infections [R].

LL-37 has demonstrated strong antibacterial effects against Staphylococcus aureus biofilms, with a more than 4 log reduction in colony counts at concentrations as low as 10 μM. Additionally, both LL-37 and its truncated mimetic KE-18 have proven effective in combating biofilms formed by Candida albicans and Staphylococcus aureus at sub-MIC concentrations [R, R].

LL-37 and Wound Healing

The topical use of synthetic and recombinant LL-37 has been demonstrated to boost the development of blood vessels and the re-growth of skin, both of which are crucial in the healing of wounds. LL-37 engages with keratinocytes and fibroblasts to stimulate the closure of wounds [R, R].

LL-37 and Immunomodulation

LL-37 can regulate bacterial invasions and control infections and inflammation. At concentrations below 1 μM, LL-37 can enhance neutrophil survival, which is important for the body’s immune response [R].

Furthermore, LL-37 immunomodulation has been suggested as a potential strategy to reduce severe COVID-19 inflammatory responses and microthrombosis. It has been shown in mouse studies that LL-37 can decrease the levels of IL-6, TNF-α, IL-1β, and macrophage pyroptosis in mice with sepsis [R].

LL-37 and Anti-Inflammatory Activity

  • Antagonistic action on pro-inflammatory cytokines: LL-37 has been shown to have an antagonistic action on IFNγ, TNF-α, IL-4, and IL-12 responses in various cell types [R].
  • Intervening in toll-like receptor signaling: LL-37 can suppress endotoxin-induced pro-inflammatory cytokines by intervening in toll-like receptor signaling [R].
  • Regulating signaling mechanisms and downstream responses: LL-37 can regulate signaling mechanisms and downstream responses induced in the presence of pro-inflammatory cytokines such as IL-32 [R].
  • Promoting the production of anti-inflammatory cytokines: LL-37 has been found to promote the production of anti-inflammatory cytokines such as interleukin-1-receptor antagonist (IL-1RA) [R].

LL-37 and Cancer Prevention

LL-37 displays an anti-cancer effect in colon cancer, gastric cancer, hematologic malignancy, and oral squamous cell carcinoma. LL-37 exhibits cancer-suppressing properties in gastric cancer cells by effectively inhibiting the proteasome in tumor tissues of the stomach [R, R].

LL-37 and Cardioprotective Effects

LL-37 has demonstrated its ability to decrease cardiac dysfunction in various preclinical heart failure models. In a study involving mice with heart failure induced by transverse aortic constriction (TAC), isoproterenol (ISO), and angiotensin II (AngII), LL-37 was observed to decrease hypertrophy and enhance cardiac function [R].
In the same research, it was demonstrated that LL-37 can provide protection against myocardial ischemia/reperfusion injury, which frequently occurs as a complication of acute myocardial infarction. This finding was confirmed in the study conducted on mice, where LL-37 exhibited the ability to decrease the size of infarcts and enhance cardiac function.
LL-37 has also demonstrated efficacy in inhibiting the advancement of atherosclerosis. In vivo analysis has revealed that LL-37 curbs the growth of plaques and triggers apoptosis in vascular smooth muscle cells, key participants in plaque formation [R].

LL-37 and Lung Health

LL-37 plays a role in protecting the body against respiratory pathogens and contributes to the effective elimination of these pathogens. This antimicrobial property of LL-37 has positive effects on the clearance of pathogens and improves clinical outcomes in individuals with chronic obstructive pulmonary disease (COPD) [R].

FAQ

What is Antimicrobial Peptide LL-37?

Antimicrobial Peptide LL-37 is a 37-residue, helical peptide with amphipathic properties that is present in various parts of the human body. It belongs to the cathelicidin family of antimicrobial peptides, which have evolved to protect eukaryotic organisms from bacterial and fungal invasion.

What Does Peptide LL-37 Do?

LL-37, also known as Human Cathelicidin Antimicrobial Peptide (CAMP) has been studied for various potential benefits. Here is a list of its main research applications:

  • Boosts immune function: LL-37 significantly enhances immune function by regulating various mechanisms involved in immune response.
  • Fights inflammation: LL-37 has strong anti-inflammatory effects, such as neutralizing TLR4 activation by LPS and downregulating inflammatory cytokine responses.
  • Has antimicrobial activity: LL-37 exhibits moderate antimicrobial activity against numerous Gram-negative and Gram-positive bacteria, including pathogens from the Pseudomonas genus.
  • Promotes wound healing: LL-37 helps stimulate faster regeneration of wounds by promoting angiogenesis and stimulating the formation of new blood vessels.
  • Controls infection: LL-37 has broad-spectrum antimicrobial activity against bacteria, enveloped viruses, and fungi, making it an effective alternative to conventional antibiotics.
  • Potential for cancer prevention: LL-37 has shown promise in preventing cancer progression, although more research is needed in this area.
  • Rapid killing of dangerous microorganisms: LL-37 features lower levels of resistance and can rapidly kill dangerous microorganisms, making it a valuable tool in combating antimicrobial resistance (AMR).

Where to Buy LL-37 Peptide

LL-37 can be purchased online from reputable biotech suppliers such as Limitless Biotech. Limitless Life offers a wide selection of USA peptides for sale online for scientific research and development purposes.

Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.

COA

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Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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