ACCOUNT

CART

$0.00
0
0
Subtotal: $0.00
No products in the cart.

KPV 5mg

$48.99

In Stock

Frequently Bought Together

Sterile Vial (10 mL)

Fast Shipping

Most orders are processed out the same day they are placed.

3rd Party Tested

Our testing lab confirms peptides sequential signatures

Research

KPV Peptide Structure

Molecular formula: C16H30N4O4
Molecular weight:
342.43 g/mol
PubChem CID: 125672
Synonyms
  • Lys-pro-val
  • 67727-97-3
  • L-Valine, N-(1-L-lysyl-L-prolyl)-
  • Msh (11-13)
  • L-Lysyl-L-prolyl-L-valine
Research Applications:
  • Anti-Inflammatory Properties
  • Antimicrobial Activity
  • Skin and Wound Healing
  • Inflammatory Bowel Disease and Colitis-Associated Cancer

What is KPV?

KPV peptide, consisting of the amino acids lysine, proline, and valine, is a tripeptide derivative of the hormone alpha-melanocyte-stimulating hormone (α-MSH). It has gained interest in scientific research due to its anti-inflammatory and immunomodulatory properties.

Anti-Inflammatory Properties of KPV

A study published in 2003 explored the anti-inflammatory effects of KPV in comparison with other MSH peptides in a model of crystal-induced peritonitis. The research found that systemic treatment with KPV significantly reduced the accumulation of polymorphonuclear leukocytes, a type of white blood cell, in the peritoneal cavity. Interestingly, the anti-inflammatory effects of KPV were distinct from those of the core MSH peptides and did not appear to be mediated through melanocortin receptors, suggesting a unique mechanism of action involving the inhibition of interleukin-1β functions [R].

Research involving immortalized human bronchial epithelial cells demonstrated that KPV suppresses inflammation by inhibiting NFκB signaling, a key regulator in inflammatory processes. The peptide’s effect involves nuclear import and stabilization of IκBα, which prevents NFκB from translocating to the nucleus and initiating inflammation. This indicates a potential therapeutic role for KPV in respiratory inflammatory diseases like asthma [R].

KPV and Antimicrobial Activity

One of the notable studies on KPV peptide highlights its efficacy against bacterial strains such as Staphylococcus aureus. Researchers have found that KPV exhibits significant antimicrobial activity, which is believed to be due to its ability to disrupt bacterial membranes, a common mechanism of action for many antimicrobial peptides [R].

Further research has explored the broader spectrum of KPV’s antimicrobial effects, including its potential against fungal pathogens. The peptide has shown activity against Candida species, which are common culprits in fungal infections in humans. This broad-spectrum activity makes KPV a promising candidate for further development into a therapeutic agent [R].

The ongoing research into KPV peptide also includes investigations into its role in biofilm prevention and disruption. Biofilms are protective layers formed by microbial communities that make them highly resistant to conventional antibiotics. Studies suggest that KPV can inhibit the formation of biofilms and disrupt existing ones, further broadening its applicability in treating persistent infections [R].

Skin and Wound Healing

Research involving animal models has shown that KPV peptide can significantly accelerate the healing process. These studies typically focus on the peptide’s ability to modulate inflammation, a critical factor in the wound healing cascade. By reducing inflammation, KPV peptide helps in quicker tissue repair and regeneration [R, R].

Although more extensive human trials are needed, preliminary studies suggest that KPV peptide can enhance wound healing in patients undergoing procedures like laser treatments. These studies assess parameters such as epithelial confluence, reduction in scarring, and overall improvement in skin texture and appearance [R].

In vitro studies have shown that KPV peptide can promote the proliferation and migration of fibroblasts and keratinocytes, which are essential for wound closure and skin regeneration. Moreover, it helps in the modulation of critical growth factors and signaling pathways involved in skin repair [R, R].

Gut Health and Barrier Function

Studies have demonstrated that KPV can effectively reduce symptoms and histological damage associated with colitis, an inflammatory condition of the colon. KPV has been shown to decrease the infiltration of inflammatory cells and the expression of inflammatory cytokines in models of colitis, thereby alleviating the disease’s severity and promoting healing of the gut lining [R].

Inflammatory Bowel Disease and Colitis-Associated Cancer

In a study that investigated the anti-inflammatory effects of KPV in two models of mice colitis, it was found that KPV, when added to drinking water, could reduce inflammation at the histologic level and decrease the expression of proinflammatory cytokines. This suggests that KPV could be a promising candidate for oral administration to manage inflammatory bowel disease (IBD) [R].

In the context of colitis-associated cancer, a condition where chronic inflammation can lead to the development of cancer, KPV’s role in promoting a healthier cellular environment may be of importance. KPV may help mitigate the progression of cancerous changes in the colon by reducing inflammation.

FAQ

Is KPV the Same as Lysine-Proline-Valine?

Yes, KPV and lysine-proline-valine are the same. KPV is a shorthand way of representing the amino acid sequence of the molecule.

What are the Potential Benefits of KPV for Future Research?

The versatility of KPV peptide in modulating inflammatory responses and its potential in treating a wide array of diseases make it a compelling subject for further scientific inquiry. Researchers can pave the way for innovative treatments that could significantly impact patient care in various medical fields by focusing on a number of research areas:

  • Inflammatory and Autoimmune Diseases
  • Skin Conditions and Wound Healing
  • Gut Health
  • Antimicrobial and Antifungal Applications
  • Neuroinflammatory Conditions
  • Cancer Research
  • Delivery Mechanisms and Formulations
  • Safety and Long-term Efficacy

Where to Buy KPV

KPV can be purchased online from reputable biotech suppliers such as Limitless Biotech. Limitless offers a wide selection of USA-made peptides for sale online for scientific research and development purposes.

Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.

COA

Certificate of Analysis for KVP 5 mg

COA_KPV_raw_lot-C-1025_2024-06-13 COA_KPV_raw_lot-C-1025_2024-06-13

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

Receive 10% off your first order!

Sign up for our newsletter and we’ll email you a code for 10% off your first order. You’ll see in the know about new products, special promotions, and exclusive items to our loyal customers.

Receive 10% off your first order!

Sign up for our newsletter and we’ll email you a code for 10% off your first order. You’ll see in the know about new products, special promotions, and exclusive items to our loyal customers.

Scroll to Top

Limitless Life Nootropics is Now...

We are changing our name simply to better reflect our commitment to providing the highest quality research peptides on the market.