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Kisspeptin-10 (5mg)


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Sterile Vial (10 mL)

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Kisspeptin-10 Product Information

Molecular formula: C63H83N17O14
Molecular weight:
1302.4 g/mol
PubChem CID 25240297
  • Kisspeptin-10
  • 374675-21-5
  • Kisspeptin-10 (human)
  • Metastin (45-54)
  • KP-10
Research Applications:
  • Testosterone
  • Reproductive Health
  • Sexual Arousal
  • Metabolism
  • Appetite Control
  • Cancer Research
  • Heart Disease

What is Kisspeptin-10?

Kisspeptin-10 is a peptide that plays a key role in the complex world of human reproduction. It’s a critical regulator of reproductive hormones, stimulating the release of gonadotropin in both men and women. It is also known to increase testosterone and luteinizing hormone (LH) pulse frequency in men. Beyond its role in reproduction, Kisspeptin-10 has been linked to metabolism and appetite control, influencing neurotransmitters in the brain. It has even been found to impact collagen content in the heart.

Kisspeptin-10 and Testosterone Levels

Kisspeptin-10 has been found to have a significant impact on testosterone levels in men:

  • A 2011 study found that kisspeptin-10 boluses strongly stimulate LH (luteinizing hormone) secretion in men. Continuous infusion of kisspeptin-10 increased testosterone, LH pulse frequency, and pulse size [R].
  • In men with type 2 diabetes and central hypogonadism, kisspeptin-10 was found to boost endogenous testosterone secretion [R].
  • Kisspeptin may provide a more physiological stimulation of the human reproductive axis. In one study, testosterone concentration significantly increased from 16.6 ± 2.4 to 24.0 ± 2.5 nmol/liter [R].
  • A study found that kisspeptin-10 robustly stimulates gonadotropin release in men but fails to stimulate gonadotropin release in women [R].

Kisspeptin-10 and Reproductive Health

In men, kisspeptin-10 stimulates the release of gonadotropin, a hormone that plays a vital role in reproductive health. In women, the effects of kisspeptin-10 are more nuanced. It stimulates gonadotropin release during the preovulatory phase of the menstrual cycle, but not during other phases. This suggests a sexual dimorphism in the responsiveness to kisspeptin-10 administration [R].

Kisspeptin-10 also has potential therapeutic uses. It has been safely and successfully used in both healthy and infertile subjects, suggesting that it could be used in the future to treat reproductive disorders. For instance, exogenous kisspeptin-54, a variant of kisspeptin, has been used as a promising method of triggering oocyte maturation in women undergoing in vitro fertilisation (IVF) treatment [R, R].

Kisspeptin-10 and Sexual Arousal

In a 2023 study, kisspeptin was found to increase happiness about sex and penile tumescence in men with HSDD, suggesting its potential as a pharmacological treatment for the disorder. This aligns with a 2017 study that showed kisspeptin enhancing limbic brain activity in response to sexual and emotional stimuli in healthy men [R, R].

In women, a 2022 study found that kisspeptin administration modulated sexual and attraction brain processing, correlating with reduced sexual aversion. This was echoed in another 2022 study, which found that kisspeptin deactivated regions that are hyperactivated in women with HSDD, enhancing sexual brain processing [R, R].

Kisspeptin-10 and Metabolism and Appetite Control

A study done in 2018 found that kisspeptin-10 can influence the expression of neuropeptide Y (NPY), a molecule that plays a key role in regulating appetite. The study also found that kisspeptin-10 can affect the levels of certain neurotransmitters, such as serotonin (5-HT) and dopamine (DA), which are involved in appetite control [R].

In 2022, researchers at UC San Diego found that kisspeptin signaling can affect body weight, energy expenditure, and feeding. This suggests that kisspeptin-10 could potentially be used to regulate these metabolic processes [R].

A 2020 study was the first to investigate the effects of kisspeptin on brain responses to visual food cues in humans. The study found that kisspeptin can affect how the brain responds to images of food, which could potentially influence appetite and eating behavior [R].

Kisspeptin-10 and Cancer Research

A 2018 study highlighted the role of kisspeptin signaling in suppressing metastasis, a process where cancer cells spread from the original tumor to other parts of the body. The study found that the anti-tumor effect of KiSS-1, the gene that encodes kisspeptin, was primarily associated with the inhibition of proliferation, migration, and cell invasion, leading to a reduction in metastasis and intratumoral microvessels [R].

In the context of breast cancer, one study demonstrated the anti-tumor effects of KP-10 on human breast cancer cell lines, both in vitro and in vivo. The study found that KP-10 inhibited the migration of breast cancer cells by regulating a process known as epithelial-mesenchymal transition [R].

KP-10’s role in angiogenesis, the formation of new blood vessels, has also been explored. One study provided evidence that KP-10 inhibits angiogenesis, which is critical for tumor growth and metastasis [R].

In another study, it was concluded that kisspeptin represses cancer metastasis via EIF2AK2 signaling, further clarifying the role of kisspeptin signaling in cancer growth and metastasis [R].

Kisspeptin-10 and Heart Disease

A 2017 study found that kisspeptin-10 can influence serum metabolism and myocardium in rats, suggesting potential therapeutic applications related to heart health. Another study in 2011 suggested that kisspeptin-10 could be a potent vasoconstrictor, affecting blood flow in the body [R, R].

In 2021, a study found that administering kisspeptin-10 regulated mTOR and AKT activities and oxidative stress in mouse cardiac tissue. This could have implications for heart disease treatment, as these pathways are often implicated in cardiovascular disorders [R].

A 2023 study found that kisspeptin-10 increased collagen content in the myocardium, which could alter the structure of myocardial cells and potentially influence heart disease progression [R].

In humans, ischemic heart disease has been associated with a decrease in cardiac kisspeptin levels. This suggests that kisspeptin-10 could play a role in the development or progression of certain types of heart disease [R].


What are the Studied Benefits of Kisspeptin 10 Peptide?

  • Kisspeptin-10 stimulates the release of luteinizing hormone (LH), which plays a key role in male reproductive health.
  • It can naturally increase the body’s production of testosterone, which is important for bone health and mood.
  • Kisspeptin-10 can help regulate fertility and increase sexual arousal.
  • It has been shown to improve mood and behavior.
  • Kisspeptin-10 has potential anti-cancer properties and can prevent the spread of cancer.
  • It can boost fertility and has been used successfully in both men and women.
  • Kisspeptin-10 can increase happiness about sex.
  • It has been found to increase the content of collagen in the heart, which could have cardioprotective properties.
  • Kisspeptin-10 can improve UV-induced skin aging, suggesting potential use for sun-damaged skin.

Does Kisspeptin Stimulate Gonadotropin-Releasing Hormone (GnRH)?

Kisspeptin-10 does stimulate the release of Gonadotropin-Releasing Hormone (GnRH). It is believed to trigger the release of GnRH from the hypothalamus, which then prompts the release of gonadotropin from the pituitary gland. [R, R, R]

Has Kisspeptin Been Studied for Melanoma?

Kisspeptin-10 has been studied in relation to melanoma. Research suggests that it may improve the sensitivity to certain inhibitors in melanoma cells that have become resistant. It has also been identified as a potential suppressor of metastasis in melanoma cells. [R, R, R]

Is There a Connection Between Kisspeptin and Melatonin?

Research suggests that melatonin and kisspeptin-10 are interconnected in their roles. Melatonin appears to regulate the production of kisspeptin, with changes in melatonin levels leading to changes in kisspeptin expression[R, R]. This interaction is thought to be a key mechanism by which melatonin influences reproductive timing. For instance, in seasonal breeders, changes in photoperiod and melatonin levels are associated with changes in kisspeptin expression[R].

Melatonin is also suggested to inhibit GnRH secretion, with kisspeptin potentially mediating this effect[R]. This suggests that melatonin could indirectly control GnRH and, therefore, reproductive function, through its influence on kisspeptin.

In addition to their roles in reproduction, both melatonin and kisspeptin-10 have been implicated in other physiological processes. For example, research in mice has shown that melatonin and kisspeptin-10 can act as tumor suppressors, with changes in their levels correlating with tumor growth[R].

Where to Buy Kisspeptin 10 for Sale Online

Kisspeptin-10 can be purchased online from reputable biotech suppliers such as Limitless Biotech. Limitless offers a wide selection of USA peptides for sale online for scientific research and development purposes.

Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.

What Peptides Have Similar Research Applications to Kisspeptin?

Several peptides have been suggested to have similar mechanisms of action and research applications to Kisspeptin-10. These include:


Certificate of Analysis for Kisspeptin-10 5 mg

Certificate of Analysis for Kisspeptin
Certificate of Analysis for Kisspeptin

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This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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