Research
Epitalon TFA Product Information
| Molecular formula: | C16H23F3N4O11 |
| Molecular weight: |
504.37Â g/mol
|
| PubChem CID: | 155977637 |
| Synonyms |
|
| Research Applications: |
|
What is Epitalon TFA?
Epitalon TFA is a synthetic peptide known for its potential anti-aging properties. It acts as a telomerase activator, which means it can stimulate the enzyme responsible for extending the protective caps at the ends of chromosomes, known as telomeres. This process is important because as cells divide, telomeres shorten, leading to aging and eventual cell death. By activating telomerase, Epitalon TFA may help maintain telomere length, potentially slowing down the aging process.
Research has shown that Epitalon TFA not only has the potential to extend lifespan but also to inhibit the development of spontaneous tumors in mice, suggesting it may have broader applications in health and disease prevention. It’s important to note that Epitalon TFA is currently available for research purposes only, and its effects have been primarily studied in animal models. The peptide’s ability to increase neuronal activity and its geroprotective actions highlight its potential as a significant tool in the study of aging and related diseases
Epitalon TFA as a Telomerase Activator
A 2003 study demonstrated that Epitalon could induce telomerase activity and elongate telomeres in human somatic cells, which are typically telomerase-negative. This finding suggests that Epitalon may reactivate the telomerase gene in these cells, potentially extending their lifespan and, by extension, that of the organism [R].
Another research effort highlighted Epitalon’s ability to stimulate gene expression and protein synthesis during neurogenesis, suggesting a possible epigenetic mechanism of action. The peptide was shown to increase the synthesis of proteins associated with neurofilament and growth, such as GAP43 and nestin, in human periodontal ligament stem cell cultures. This indicates that Epitalon may have a regulatory effect on cellular functions, including proliferation and differentiation, which could be connected to its impact on telomere length and telomerase activity [R].
