Bromantane Fact Sheet
Bromantane (Ladasten) is a “actoprotector”: Actoprotectors improve body stability against physical stresses without raising oxygen consumption or heat. Actoprotectors are metabolic molecules with antihypoxic properties. They vary from antihypoxants by directly stimulating protein synthesis and working capability. Similar to stimulants, yet different: Actoprotectors are non-exhaustive. Actoprotectors boost not only cerebral (intellectual) but also physical work capacity, unlike nootropics.
Bromantane and Physical Performance
Bromantane is an adamantane derivative that has been shown to enhance physical performance and muscle strength in animal studies. It has a low toxicity and a high ability to enhance the physical and operant working maintenance of animals, as well as accelerate recovery in developed fatigue, hyperthermia, and hypoxia. In a study done on rats, bromantane treatment increased muscle strength and optimized operant activity during the first month of the course. The mechanism of action for bromantane’s therapeutic effects is thought to involve catecholaminergic effects.
Although the majority of research on bromantane has been conducted on animals, its potential to improve physical performance and muscle strength in humans is promising. As an actoprotector, bromantane is a synthetic adaptogen with a significant capacity to improve physical performance.
Bromantane and Anxiolytic Effects
The anxiolytic effects of bromantane are part of its broad pharmacological spectrum. Anxiolytics are drugs that help reduce anxiety. The mechanism of action for bromantane’s anxiolytic effects is thought to be related to its influence on the dopaminergic system. It has been demonstrated that bromantane induces a pronounced and prolonged increase in the release of dopamine, a neurotransmitter that plays a significant role in reward, motivation, and stress.
Bromantane’s therapeutic action is believed to be due to its catecholaminergic effects, which involve the neurotransmitters dopamine, norepinephrine, and epinephrine. These neurotransmitters are known to play a role in mood regulation, including anxiety.
Bromantane’s Neuroprotective and Adaptogenic Properties
Neuroprotective properties of Bromantane are attributed to its ability to increase the expression of neurotrophins, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), in certain areas of the rat brain. These neurotrophins play a crucial role in the survival, growth, and maintenance of neurons, which may contribute to the overall neuroprotective effects of Bromantane.
As an adaptogen, Bromantane helps the body adapt to stress without increasing oxygen consumption or heat production. It has been shown to enhance GABAergic transmission and suppress the expression of genes that control the synthesis of GABA transporters. This adaptogenic property of Bromantane may contribute to the improvement of mental and physical performance under stressful conditions.