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ARA-290 (8mg)

$50.99

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Glass Vial

Presentation

Solid Crystals

Add'l Information

10mL Phosphate buffered bacteriostatic water, Empty Vial

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Research

ARA-290 Peptide Overview

ARA-290 is a peptide that has been engineered from erythropoietin (EPO). It is a nonhematopoietic peptide designed to interact selectively with the innate repair receptor, which mediates tissue protection. Here is an overview of ARA-290:

  • ARA-290 is an 11-amino acid peptide that is based on the structure of helix B of the EPO molecule.
  • It has shown efficacy in preclinical and clinical studies of metabolic control and neuropathy.
  • ARA-290 has undergone extensive evaluation in various preclinical models, including those for insulin resistance, diabetic retinopathy, diabetic autonomic neuropathy, myocardial infarction, chronic heart failure, burns, traumatic brain injury, and shock-induced multi-organ failure.
  • It has been found to prevent tissue damage, reduce inflammation, and promote healing.
  • ARA-290 is a linear peptide consisting of 11 amino acids and has a molecular weight of 1257 daltons.
  • ARA-290 has completed phase II trials and is now preparing for phase III trials in the treatment of conditions such as diabetes and autoimmune sarcoidosis.
  • It has potential applications in treating neuropathic pain, promoting wound healing in chronic diabetes, modulating the immune system, and managing systemic lupus erythematosus.
  • ARA-290 provides pain relief and neuroprotection without stimulating red blood cell production.
  • It has been shown to reduce inflammation, chronic pain, and promote healing.

ARA-290 Peptide Structure

PubChem CID: 91810664

Molecular Formula: C51H84N16O21

Synonyms: Cibinetide, ARA290, 1208243-50-8, PHBSP, PH-BSP

Molecular Weight: 1257.3 g/mol

ARA-290 and Inflammation

ARA-290 is a peptide that has been extensively studied for its impact on inflammation and pain relief. Here is an overview into research on the effects of ARA-290 on inflammation:

  • ARA-290 exhibits analgesic properties by exerting anti-inflammatory and immunomodulatory functions. It specifically targets the innate repair receptor (IRR) to reduce inflammation and alleviate neuropathic pain.
  • Activation of the IRR through ARA-290 triggers a localized anti-inflammatory response and facilitates tissue repair. It can inhibit cell death signals, prevent tissue damage, and promote the growth of nerve fibers in the nervous system.
  • Animal studies have demonstrated that ARA-290 possesses tissue-protective effects and can effectively reduce inflammation. It has shown promise in improving survival rates after myocardial infarction, mitigating organ dysfunction in hemorrhagic shock, and suppressing the development of atherosclerosis.
  • ARA-290 has been extensively evaluated in various preclinical models and has consistently demonstrated its ability to prevent tissue injury, reduce inflammation, and promote healing. It has been investigated in conditions such as diabetic retinopathy, burns, traumatic brain injury, and multi-organ failure.
  • Research has revealed that ARA-290 can reduce inflammation in nerves, stimulate the formation of new blood vessels, decrease cytokine levels, and inhibit the inflammatory cytokine TNF-a. It also exhibits anti-inflammatory effects on Schwann cells and promotes their proliferation.

References:

https://pubmed.ncbi.nlm.nih.gov/26774587/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928087/

https://www.frontiersin.org/articles/10.3389/fphar.2022.896601/full

https://molmed.biomedcentral.com/articles/10.2119/molmed.2014.00215

https://molmed.biomedcentral.com/articles/10.2119/molmed.2013.00122

ARA-290 and Tissue Protection

ARA-290 is a non-erythropoietic peptide that is designed to activate the innate repair receptor (IRR) and mediate tissue protection.  It reduces inflammation and fibrotic responses by signaling through a receptor composed of EPOR and CD131, the β common cytokine receptor. ARA-290 prevents tissue injury, reduces inflammation, and promotes healing. It works by activating the IRR, which inhibits the production and action of proinflammatory cytokines. In preclinical injury models, ARA-290 inhibits TNFα and other proinflammatory cytokines.

ARA-290 possesses tissue-protective and tissue-regenerative properties. It interacts with the innate repair receptor to promote tissue repair, reduce inflammation, and prevent cell death. ARA-290 selectively targets the innate repair receptor to exert its regenerative effects on various body tissues. Extensive scientific evidence supports the beneficial effects of ARA-290 on different types of tissue injuries. In rat studies, ARA-290 effectively protected against early renal allograft injury by reducing macrophage infiltration. Additionally, ARA-290 has been shown to attenuate small nerve fiber loss and neuritis associated with type 2 diabetes-induced neuropathy.

References:

https://www.frontiersin.org/articles/10.3389/fcvm.2022.1096887/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365069/

https://molmed.biomedcentral.com/articles/10.2119/molmed.2012.00332

https://www.frontiersin.org/articles/10.3389/fphar.2022.896601/full

ARA-290 and Pain Relief

ARA-290, a peptide derived from erythropoietin, has been studied for its potential in providing pain relief, specifically in neuropathic pain conditions. The search results indicate the following findings regarding ARA-290 and pain relief:

  • ARA290 activates the β-common receptor, leading to long-term relief of allodynia, a type of pain sensitivity. It is believed that the anti-inflammatory properties of ARA290, possibly within the central nervous system, contribute to the relief of neuropathic pain associated with its treatment.
  • ARA290 shows promise as a drug for preventing peripheral nerve injury-induced neuropathic pain in humans, as it does not have hematopoietic and cardiovascular side effects.
  • According to a study, more frequent dosing of ARA290 may be necessary to prevent an increase in pain over time, given its biologic half-life of less than 1 week.
  • ARA290 has demonstrated analgesic and tissue protective effects in various diseases such as diabetes and cancer.
  • In patients with type 2 diabetes, ARA290 has shown potential in improving metabolic control and alleviating neuropathic symptoms.
  • ARA290, as an innate repair receptor (IRR) agonist, has been associated with increased energy and pain relief.

References:

https://pubs.asahq.org/anesthesiology/article/115/5/1084/12842/ARA290-a-Peptide-Derived-from-the-Tertiary

https://pubmed.ncbi.nlm.nih.gov/26774587/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365069/

https://www.frontiersin.org/articles/10.3389/fphar.2022.896601/full

FAQ

What is ARA-290?

ARA-290 is a peptide that has been engineered from the structure of erythropoietin (EPO) . It interacts selectively with the innate repair receptor, which mediates tissue protection. ARA-290 is designed to activate the innate repair receptor, which antagonizes inflammatory processes and stimulates tissue repair. ARA-290 does not stimulate red blood cell production like erythropoietin (EPO), but it offers pain-relieving and neuroprotective effects.

What are the Researched Benefits of ARA-290?

ARA-290 has been researched for several benefits, including:

  • Pain Management: ARA-290 has been shown to reduce chronic pain.
  • Reduces Inflammation: ARA-290 has anti-inflammatory properties that can help reduce inflammation.
  • Promotes Healing & Recovery: ARA-290 has been shown to activate healing and promote tissue repair.
  • Nerve Repair & Regeneration: ARA-290 has been shown to induce small nerve fiber regeneration.
  • Immune-modulating Properties: ARA-290 has immune-modulating properties that can help ward off a wide array of diseases.
  • Anti-diabetic Properties: ARA-290 possesses potent anti-diabetic properties that can be beneficial in patients with diabetes mellitus and chronically elevated blood sugar levels.

ARA-290 does not stimulate red blood cell production like EPO, but it does provide pain relief and neuroprotection. It has the ability to reduce inflammation through paracrine signaling. While further research is needed to fully understand the benefits of ARA-290, it has shown potential in alleviating chronic pain, inflammation, and aiding in healing and recovery.

How Does ARA-290 Work?

ARA-290 binds to the innate repair receptor and activates it, leading to anti-inflammatory and tissue repair effects. It can help reduce neuropathic symptoms and promote nerve fiber regeneration.

Has ARA-290 Been Used for Type 2 Diabetes?

ARA-290 has shown efficacy in improving metabolic control and reducing neuropathic symptoms in patients with type 2 diabetes. It acts as an erythropoietin mimetic peptide, providing therapeutic benefits without affecting red blood cell production.

Has ARA-290 Been Used for Conditions Other Than Neuropathy?

ARA-290 has been studied for its potential use in various conditions, including sarcoidosis and small nerve fiber loss. Its anti-inflammatory and tissue protective properties may provide benefits in different inflammatory and tissue damage scenarios.

Is ARA 290 an Anti-Inflammatory Cytokine?

ARA-290 is not an anti-inflammatory cytokine itself, but it can modulate the production of inflammatory cytokines. By reducing inflammation, it helps in tissue protection and repair.

What is the Mechanism of Action of ARA 290?

ARA-290 produces its effects via activation of the β-common-receptor in conjunction with the EPO receptor, which forms a heterocomplex designated the IRR. The IRR becomes locally up-regulated following tissue injury. In addition to a central nervous system effect, modulation of the peripheral nerve immune response could also be part of the mechanism of action of ARA-290, but these specific effects remain to be investigated.

Where to Buy ARA-290

ARA-290 can be purchased online from reputable biotech suppliers such as Limitless Life. Limitless Life offers a wide selection of research-grade peptides for sale online for scientific research and development purposes.

Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.

COA

ARA-290 (8mg)

COA_ARA-290_1163_57_r1_2024_07_09 COA_ARA-290_1163_57_r1_2024_07_09 COA_ARA-290_1163_57_r1_2024_07_09 COA_ARA-290_1163_57_r1_2024_07_09 COA_ARA-290_1163_57_r1_2024_07_09 COA_ARA-290_1163_57_r1_2024_07_09 COA_ARA-290_1163_57_r1_2024_07_09 COA_ARA-290_1163_57_r1_2024_07_09

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

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