Research
AOD 9604 Peptide Structure
| Molecular formula: | C78H125N23O23S2 |
| Molecular weight: |
1817.1ย g/mol
|
| PubChem CID: | 16131447 |
| Synonyms |
|
| Research Applications: |
|
What is AOD-9604?
AOD-9604 is a synthetic peptide and modified fragment of hGH, specifically the C-terminal region (amino acids 177-191). It was developed with the intention of mimicking the fat-burning properties of hGH without its muscle-building effects, which are not always desired in the context of weight loss.
How AOD-9604 Works
AOD-9604 stimulates the pituitary gland, similar to how natural growth hormones regulate fat metabolism. It activates lipolysis, the breakdown of fats, and inhibits lipogenesis, the formation of fats. The peptide has been shown to reduce body weight in animal studies and in some human trials.
AOD-9604 and Metabolic Health
Research has shown that AOD-9604 can influence lipid metabolism in several ways. It has been observed to increase lipolysis, which is the breakdown of fat, and reduce lipogenesis, the process of transforming non-fat food materials into body fat [R].
These effects were noted in obese mice and beta(3)-adrenergic receptor knock-out mice, suggesting that AOD-9604’s actions are not mediated directly through the beta(3)-adrenergic receptor, a known facilitator of lipolysis [R].
AOD-9604 and Weight Loss
Research hasย shown that AOD-9604 can stimulateย lipolysisโthe breakdownย of fatโand inhibitย lipogenesis, theย transformationย of non-fat foodย materials intoย body fat. Inย animal studies, AOD-9604 hasย been found toย reduce body weightย without significantlyย affecting bloodย sugar levels, which is a commonย side effect ofย other weightย loss drugs [R][R].
Clinical trials have shown positive results regarding the efficacy of AOD-9604 for weight loss in humans, with one study reporting an average loss of 2.6 kg over 12 weeks, compared to 0.8 kg in the placebo group [R].
AOD-9604 and Musculoskeletal Health
Beyond its potential for weight loss, AOD-9604 has also shown promise in promoting bone and cartilage repair, which could be beneficial for conditions like osteoarthritis and osteoporosis.
In a rabbit osteoarthritis model, intra-articular AOD-9604 injections enhanced cartilage regeneration, and combined AOD-9604 and hyaluronic acid (HA) injections were more effective than HA or AOD-9604 injections alone. According to the study, AOD-9604’s safety profile and lack of growth hormone receptor agonism suggest it may be safer for long-term treatment of osteoarthritis compared to human growth hormone [R].
