9-Me-BC Powder (500mg)

What is 9-Me-BC?

9-Me-BC, or 9-Methyl-β-carboline, is a compound of interest in the scientific community for its potential effects on the brain. It belongs to the β-carboline family, a group of compounds known for their presence in various plants and animals, as well as for their ability to influence brain functions. 

Research has shown that 9-Me-BC may have several beneficial effects on the nervous system. It has been observed to inhibit monoamine oxidase activity, which could lead to increased levels of neurotransmitters like dopamine. This inhibition, along with its ability to stimulate the expression of neurotrophic factors by astrocytes, suggests that 9-Me-BC could have neuroprotective and neurostimulative properties.

9-Me-BC and Parkinson’s Disease

In a 2010 study, 9-Me-BC was found to stimulate, protect, and regenerate dopaminergic neurons, which are primarily affected in Parkinson’s disease. The study also noted anti-inflammatory effects of 9-Me-BC, which could be beneficial in reducing neuroinflammation, a common feature in neurodegenerative diseases [R].

Another study from 2020 found that 9-Me-BC not only inhibits monoamine oxidase activity but also stimulates the expression of neurotrophic factors by astrocytes. These factors are known to stimulate neurite outgrowth and show neuroprotective and neuroregenerative effects. The study also found that 9-Me-BC decreased the protein levels of α-synuclein, a protein that forms harmful clumps in the brains of people with Parkinson’s disease [R].

9-Me-BC and Cognitive Function

Research has shown that 9-Me-BC can enhance cognitive function, particularly in tasks that depend on the hippocampus. This enhancement is associated with increased dopamine levels in the hippocampus and the development of more complex dendritic trees and higher spine numbers on granule neurons in the dentate gyrus [R].

In addition to its cognitive enhancement properties, 9-Me-BC has been found to have neuroprotective and neuroregenerative effects. It can stimulate the growth of neurons and neurites, and it has anti-inflammatory properties. 9-Me-BC is also a known inhibitor of monoamine oxidase A, an enzyme responsible for the degradation of dopamine. This means that in addition to enhancing dopamine synthesis, 9-Me-BC likely increases circulating levels of dopamine by preventing its breakdown [R].

Lastly, 9-Me-BC has been found to stimulate the gene expression of several important neurotrophic factors for dopaminergic neurons, including Artn, Bdnf, Egln1, Tgfb2, and Ncam1. These factors are known to stimulate neurite outgrowth and exhibit neuroprotective properties [R].

9-Me-BC and Neuroprotection

9-Methyl-β-carboline (9-me-BC) is a compound that has shown promising effects in the realm of neuroprotection and neuroinflammation. Research indicates that it has the potential to stimulate, protect, and regenerate dopaminergic neurons, which are crucial in the functioning of the brain‘s reward system and motor control [R]. 

One of the key findings is that 9-me-BC inhibits monoamine oxidase activity. Monoamine oxidases are enzymes that break down neurotransmitters like dopamine, norepinephrine, and serotonin. By inhibiting these enzymes, 9-me-BC may help maintain higher levels of these neurotransmitters in the brain, which could be beneficial for conditions like depression and Parkinson’s disease [R].

Inflammation in the brain is linked to a number of neurological conditions, including Alzheimer’s disease and multiple sclerosis. 9-me-BC has shown anti-inflammatory effects that could potentially help protect against several neuroinflammatory conditions.